ArticleEukaryotic cell2003
The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development.
Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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Who cites it
108 citing papers in PubMed, 232 citations in OpenAlex.
- When growth becomes risky: stress-driven sporulation and sexual development in fungi.Stress biology · 2026Review
- Domain-Targeted RNAi of VeA Reveals Its Essential Role in the Fusarium oxysporum-Pseudostellaria heterophylla Interaction.Molecular plant pathology · 2026Article
- Members of Velvet Complex FpVeA and FpVelB Regulate Asexual Development, Fumonisin Biosynthesis and Virulence inFoods (Basel, Switzerland) · 2025Article
- Engineering of Global Transcriptional Regulators (GTRs) inJournal of fungi (Basel, Switzerland) · 2025Review
- Article
- Involvement of LaeA and Velvet Proteins in Regulating the Production of Mycotoxins and Other Fungal Secondary Metabolites.Journal of fungi (Basel, Switzerland) · 2024Review
- The GeneToxins · 2024Article
- Phylogenomics analysis of velvet regulators in the fungal kingdom.Microbiology spectrum · 2024Article
- An ascomycete H4 variant with an unknown function.Royal Society open science · 2024Article
- Article
- Light regulation of secondary metabolism in fungi.Journal of biological engineering · 2023Review
- srdA mutations suppress the rseA/cpsA deletion mutant conidiation defect in Aspergillus nidulans.Scientific reports · 2023Article
- Review
- Fungal-fungal cocultivation leads to widespread secondary metabolite alteration requiring the partial loss-of-function VeA1 protein.Science advances · 2022Article
- Roles of AaFrontiers in microbiology · 2022Article
- Epigenetic Modification: A Key Tool for Secondary Metabolite Production in Microorganisms.Frontiers in microbiology · 2022Review
- The DUG Pathway Governs Degradation of Intracellular Glutathione in Aspergillus nidulans.Applied and environmental microbiology · 2021Article
- The velvet protein Vel1 controls initial plant root colonization and conidia formation for xylem distribution in Verticillium wilt.PLoS genetics · 2021Article
- Endophytic Fungi: From Symbiosis to Secondary Metabolite Communications or Vice Versa?Frontiers in plant science · 2021Review
- Regulation of Secondary Metabolism in theInternational journal of molecular sciences · 2020Review
48 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary metabolism is commonly associated with morphological development in microorganisms, including fungi. We found that veA, a gene previously shown to control the Aspergillus nidulans sexual/asexual developmental ratio in response to light, also controls secondary metabolism. Specifically, veA regulates the expression of genes implicated in the synthesis of the mycotoxin sterigmatocystin and the antibiotic penicillin. veA is necessary for the expression of the transcription factor aflR, which activates the gene cluster that leads to the production of sterigmatocystin. veA is also necessary for penicillin production. Our results indicated that although veA represses the transcription of the isopenicillin synthetase gene ipnA, it is necessary for the expression of acvA, the key gene in the first step of penicillin biosynthesis, encoding the delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase. With respect to the mechanism of veA in directing morphological development, veA has little effect on the expression of the known sexual transcription factors nsdD and steA. However, we found that veA regulates the expression of the asexual transcription factor brlA by modulating the alpha/beta transcript ratio that controls conidiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.