Evidence map›Paper›PMID 14664760›Full record

ReviewCurrent oncology reports2004

A role for antiangiogenic therapy in breast cancer.

Marsha A Moses, Jay Harper, Cecilia A Fernández

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marsha A MosesVascular Biology Program, Children's Hospital, Enders 1009, 320 Longwood Avenue, Boston, MA 02115, USA. marsha.moses@tch.harvard.edu
Jay Harper
Cecilia A Fernández

Funding

TUMOR DORMANCY INDUCED BY BLOCKED ANGIOGENESISP01CA045548 · NCI · CHILDREN'S HOSPITAL BOSTON · PI KLAGSBRUN, MICHAEL · 1987 to 2011
$22.6M
ANGIOGENESIS INHIBITORS FROM SHARK CARTILAGER01AT000650 · NCCIH · CHILDREN'S HOSPITAL BOSTON · PI LANGER, ROBERT S · 2001 to 2003
$1.1M
NOVEL ANGIOGENESIS INHIBITOR FROM CARTILAGER01CA083106 · NCI · CHILDREN'S HOSPITAL BOSTON · PI MOSES, MARSHA A · 1999 to 2002
$711k
NCCIH NIH HHS AT00650NCI NIH HHS 2P01CA45548NCI NIH HHS CA83106
6 · The paper itself

Abstract

The success of the angiogenesis inhibitor bevacizumab, the vascular endothelial growth factor antagonist that was recently shown to significantly improve the survival of patients with metastatic colon cancer when administered in combination with conventional chemotherapy, has provided proof of principle in clinical trials that antiangiogenesis can be an important strategy in the treatment of cancer. This report reviews the contemporary therapeutic approaches for breast cancer, the essential role that angiogenesis plays in the initiation and progression of this disease, and the strategies that should be considered to make antiangiogenic therapy a successful component of breast cancer treatment.

Indexed as

Angiogenesis InhibitorsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBevacizumabBreast NeoplasmsEndothelium, VascularFemaleHumansNeovascularization, PathologicPrognosisWomen's HealthAngiogenesis InhibitorsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBevacizumab

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.