ReviewDrugs2003
What is the role of NSAIDs in pre-emptive analgesia?
Review in Drugs, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 95 citations in OpenAlex.
- Efficiency of Immediate and Controlled release of Aceclofenac on Post-instrumentation Pain in Root Canal Treatment - A Triple Blind Randomized Controlled Trial.European endodontic journal · 2023Trial
- Role of Parecoxib Sodium in the Multimodal Analgesia after Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial.Orthopaedic surgery · 2018Trial
- Effects of preemptive analgesia with flurbiprofen ester on lymphocytes and natural killer cells in patients undergoing esophagectomy: A randomized controlled pilot study.Thoracic cancer · 2017Trial
- Comparing parecoxib and ketorolac as preemptive analgesia in patients undergoing posterior lumbar spinal fusion: a prospective randomized double-blinded placebo-controlled trial.BMC musculoskeletal disorders · 2015Trial
- A comparison of pre and post-operative vedaprofen with ketoprofen for pain control in dogs.BMC veterinary research · 2015Trial
- Assessment of preemptive analgesia with ibuprofen coadministered or not with dexamethasone in third molar surgery: a randomized double-blind controlled clinical trial.Oral and maxillofacial surgery · 2013Trial
- Effects of preemptive analgesia in laparoscopic cholecystectomy: a double-blind randomized controlled trial.Surgical endoscopy · 2011Trial
- Lack of preemptive analgesia by intravenous flurbiprofen in thyroid gland surgery: a randomized, double-blind and placebo-controlled clinical trial.International journal of medical sciences · 2011Trial
- Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy.Journal of feline medicine and surgery · 2009Trial
- Postoperative analgesic effect of preoperative intravenous flurbiprofen in arthroscopic rotator cuff repair.Journal of anesthesia · 2009Trial
- Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery.Journal of anesthesia · 2006Trial
- Nonsteroidal anti-inflammatory drug (NSAID) premedication for pain-free inferior alveolar nerve block: a systematic review and meta-analysis.Journal of dental anesthesia and pain medicine · 2026Review
- Onset of Analgesia in Rats (Rattus norvegicus) for Three Buprenorphine Formulations.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Bridging Evidence Synthesis and Clinical Relevance in Blood-Letting Therapy for Knee Osteoarthritis: Methodological Reflections on a Meta-Analysis [Letter].Journal of pain research · 2026Article
- From gut-reproductive microbiota to ferroptosis: a comprehensive insight into the molecular-pathogenicity of endometriosis.Frontiers in immunology · 2026Review
- Welfare of beef cattle.EFSA journal. European Food Safety Authority · 2025Article
- Perioperative Pain Management for Mastectomy in Dogs: A Narrative Review.Animals : an open access journal from MDPI · 2025Review
- Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old Goats.Animals : an open access journal from MDPI · 2022Article
- The effect of breed, sex, and oral meloxicam administration on pain biomarkers following hot-iron branding in Hereford and Angus calves.Journal of animal science · 2022Article
- Assessment of pain associated with bovine respiratory disease and its mitigation with flunixin meglumine in cattle with induced bacterial pneumonia.Journal of animal science · 2022Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
NSAIDs inhibit the cyclo-oxygenase enzymes, and decrease peripheral and central prostaglandin production. In addition to reducing the inflammation that accompanies tissue injury, decreasing prostaglandin production attenuates the response of the peripheral and central components of the nervous system to noxious stimuli. Such a reduction in the response to pain can reduce the peripheral and central sensitisation induced by noxious stimuli, and reduce the pain experienced in response to subsequent noxious stimuli. These properties would seem to make NSAIDs ideal drugs to use in a pre-emptive fashion, where analgesics are administered prior to a noxious stimulus, such as surgery, with the expectation that reduction in peripheral and central sensitisation will lead to a decrease of pain.However, the available perioperative trials of pre-emptive NSAID use have yielded modest or equivocal results, and these may be due, in part, to controversy associated with the definition of pre-emptive analgesia and how to conduct the corresponding clinical trials. Although NSAIDs may have a limited ability by themselves to induce a pre-emptive analgesic effect, the available trials suggest how the perioperative use of these drugs may be made more effective. It is expected that NSAIDs will play an increasing role in multimodal analgesia and pain relief in general.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.