ArticleThe Journal of cell biology2003
Meiotic condensin is required for proper chromosome compaction, SC assembly, and resolution of recombination-dependent chromosome linkages.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 84 citations in OpenAlex.
- Orchestrating homolog segregation in meiosis I: molecular logic and regulatory networks with emphasis on male metaphase I.Cell communication and signaling : CCS · 2026Review
- SUMO mediates the coordinate regulation of meiotic chromosome length and crossover rate.bioRxiv : the preprint server for biology · 2026Article
- Article
- Crossover designation recruits condensin to reorganize the meiotic chromosome axis.Current biology : CB · 2025Article
- Crossover designation recruits condensin to reorganize the meiotic chromosome axis.bioRxiv : the preprint server for biology · 2025Article
- Regulation of condensin II by self-suppression and release mechanisms.Molecular biology of the cell · 2024Article
- Meiosis in budding yeast.Genetics · 2023Article
- NCAPH Stabilizes GEN1 in Chromatin to Resolve Ultra-Fine DNA Bridges and Maintain Chromosome Stability.Molecules and cells · 2022Article
- Histone variant H2A.Z promotes meiotic chromosome axis organization in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2022Article
- Review
- Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans.Journal of cell science · 2021Article
- Interplay between Pds5 and Rec8 in regulating chromosome axis length and crossover frequency.Science advances · 2021Article
- SUMO is a pervasive regulator of meiosis.eLife · 2021Article
- Chromosome Organization in Early Meiotic Prophase.Frontiers in cell and developmental biology · 2021Review
- Condensin I is required for faithful meiosis in Drosophila males.Chromosoma · 2020Article
- Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase.Nucleic acids research · 2019Article
- The nature of meiotic chromosome dynamics and recombination in budding yeast.Journal of microbiology (Seoul, Korea) · 2019Review
- Condensin Depletion Causes Genome Decompaction Without Altering the Level of Global Gene Expression inGenetics · 2018Article
- Condensins promote chromosome individualization and segregation during mitosis, meiosis, and amitosis inMolecular biology of the cell · 2018Article
- Reduced dosage of the chromosome axis factor Red1 selectively disrupts the meiotic recombination checkpoint in Saccharomyces cerevisiae.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Condensin is an evolutionarily conserved protein complex that helps mediate chromosome condensation and segregation in mitotic cells. Here, we show that condensin has two activities that contribute to meiotic chromosome condensation in Saccharomyces cerevisiae. One activity, common to mitosis, helps mediate axial length compaction. A second activity promotes chromosome individualization with the help of Red1 and Hop1, two meiotic specific components of axial elements. Like Red1 and Hop1, condensin is also required for efficient homologue pairing and proper processing of double strand breaks. Consistent with these functional links condensin is necessary for proper chromosomal localization of Red1 and Hop1 and the subsequent assembly of the synaptonemal complex. Finally, condensin has a Red1/Hop1-independent role in the resolution of recombination-dependent linkages between homologues in meiosis I. The existence of distinct meiotic activities of condensin (axial compaction, individualization, and resolution of recombination-dependent links) provides an important framework to understand condensin's role in both meiotic and mitotic chromosome structure and function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.