ArticleBritish journal of pharmacology2004
Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis.
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Macrophage modulation accounts for the anti-inflammatory effect of Hypnea cervicornis agglutinin in rat arthritis induced by zymosan.Glycoconjugate journal · 2026Article
- Effect of gamma-terpinene on the articular inflammatory response.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- 1,4-Diaryl-1,2,3-triazole neolignan-celecoxib hybrids inhibit experimental arthritis induced by zymosan.Inflammopharmacology · 2023Article
- Article
- Metabolomic Signature of Amino Acids, Biogenic Amines and Lipids in Blood Serum of Patients with Severe Osteoarthritis.Metabolites · 2020Article
- Crude extract from Libidibia ferrea (Mart. ex. Tul.) L.P. Queiroz leaves decreased intra articular inflammation induced by zymosan in rats.BMC complementary and alternative medicine · 2019Article
- A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage.BioMed research international · 2016Article
- Consequences of metabolic and oxidative modifications of cartilage tissue.Nature reviews. Rheumatology · 2015Review
- Anti-inflammatory and immunomodulatory effect of an extract of Coccidioides posadasii in experimental arthritis.Mycopathologia · 2013Article
- Ameliorative effect of p-coumaric acid, a common dietary phenol, on adjuvant-induced arthritis in rats.Rheumatology international · 2013Article
- Efficacy of Bacopa monniera (L.) Wettst in alleviating lysosomal instability in adjuvant-induced arthritis in rats.Inflammation · 2011Article
- Inhibition of pro-inflammatory mediators: role of Bacopa monniera (L.) Wettst.Inflammopharmacology · 2011Article
- Tadalafil analgesia in experimental arthritis involves suppression of intra-articular TNF release.British journal of pharmacology · 2011Article
- Experimental model of zymosan-induced arthritis in the rat temporomandibular joint: role of nitric oxide and neutrophils.Journal of biomedicine & biotechnology · 2011Article
- Combined glucosamine and chondroitin sulfate provides functional and structural benefit in the anterior cruciate ligament transection model.Clinical rheumatology · 2009Article
- Protective effect of an extract from Ascaris suum in experimental arthritis models.Infection and immunity · 2008Article
- Nitric oxide in inflammation and pain associated with osteoarthritis.Arthritis research & therapy · 2008Review
- Antioxidants block cyclic loading induced chondrocyte death.The Iowa orthopaedic journal · 2007Article
- Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis.Naunyn-Schmiedeberg's archives of pharmacology · 2007Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The contribution of nitric oxide (NO) and peroxynitrite (PN) to inflammation in a zymosan-induced (1 mg, intra-articular, i.art.) rat model of arthritis was assessed by histopathology and by measuring the glycosaminoglycan (GAG) content of the articular cartilage. 2. Progression of the chronic synovitis in zymosan-induced arthritis (ZYA) was associated with increased nitrite and nitrotyrosine (3-NT) levels in the joint exudates that paralleled a progressive loss of the GAG content. An increase in 3-NT was also observed after i.art. PN. 3. The nonselective nitric oxide synthase (NOS) inhibitor l-N(G)-nitroarginine methyl ester (25-75 mg x kg(-1)day(-1)) or the selective inducible NOS inhibitor aminoguanidine (50-100 mg x kg(-1)day(-1)) given 1 h before (prophylactic) or 3 days after (therapeutic) injection of the zymosan ameliorated the synovitis, but worsened the GAG loss, as measured at the end of the experiment (day 7). 4. The PN scavenger uric acid (100-250 mg x kg(-1) i.p. four times daily) given prophylactically until the end of the experiment (day 14), in a dose compatible with its PN scavenging activity, significantly decreased both the synovitis and the GAG loss. 5. In conclusion, PN formation is associated with cartilage damage in addition to proinflammatory activity in ZYA. NOS inhibitors and a PN scavenger were able to reduce the cellular infiltration, while displaying opposite effects on cartilage homeostasis either by enhancing or ameliorating the damage, respectively.
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