ArticlePharmaceutical research2003
A physiologic model for simulating gastrointestinal flow and drug absorption in rats.
Article in Pharmaceutical research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 100 citations in OpenAlex.
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- Model-based optimization of controlled release formulation of levodopa for Parkinson's disease.Scientific reports · 2023Article
- The Rat Continuous Intestine Model Predicts the Impact of Particle Size and Transporters on the Oral Absorption of Glyburide.Molecular pharmaceutics · 2023Article
- Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function.Frontiers in physiology · 2021Review
- A workflow to build PBTK models for novel species.Archives of toxicology · 2020Article
- The Segregated Intestinal Flow Model (SFM) for Drug Absorption and Drug Metabolism: Implications on Intestinal and Liver Metabolism and Drug-Drug Interactions.Pharmaceutics · 2020Review
- Experiments and modeling of controlled release behavior of commercial and model polymer-drug formulations using dialysis membrane method.Drug delivery and translational research · 2020Article
- Building in-house PBPK modelling tools for oral drug administration from literature information.ADMET & DMPK · 2019Article
- Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits.PloS one · 2018Article
- Continuous Intestinal Absorption Model Based on the Convection-Diffusion Equation.Molecular pharmaceutics · 2017Article
- Article
- A novel suspension formulation enhances intestinal absorption of macromolecules via transient and reversible transport mechanisms.Pharmaceutical research · 2014Article
- Incorporation of physiologically based pharmacokinetic modeling in the evaluation of solubility requirements for the salt selection process: a case study using phenytoin.The AAPS journal · 2013Article
- A detailed physiologically based model to simulate the pharmacokinetics and hormonal pharmacodynamics of enalapril on the circulating endocrine Renin-Angiotensin-aldosterone system.Frontiers in physiology · 2013Article
- Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification.In silico pharmacology · 2013Article
- Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling.British journal of clinical pharmacology · 2012Article
- Integrating cellular metabolism into a multiscale whole-body model.PLoS computational biology · 2012Article
- Physiologically Based Pharmacokinetic Modeling of Tamoxifen and its Metabolites in Women of Different CYP2D6 Phenotypes Provides New Insight into the Tamoxifen Mass Balance.Frontiers in pharmacology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe development of a physiologically based absorption model for orally administered drugs in rats is described.
methodsUnlike other models that use a multicompartmental approach, the GI tract is modeled as a continuous tube with spatially varying properties. The mass transport through the intestinal lumen is described via an intestinal transit function. The only substance-specific input parameters of the model are the intestinal permeability coefficient and the solubility in the intestinal fluid. With this physiologic and physicochemical information, the complete temporal and spatial absorption profile can be calculated.
resultsA first performance test using portal concentration data published in the literature yielded an excellent agreement between measured and simulated temporal absorption profiles in the portal vein. Furthermore, the dose dependence of a compound with solubility-limited fraction dose absorbed in rats (chlorothiazide) could be adequately described by the model.
conclusionsThe continuous absorption model is well suited to simulate drug flow and absorption in the GI tract of rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.