ArticleVirchows Archiv. A, Pathological anatomy and histopathology1992
Expression of transforming growth factor alpha in human tissues: immunohistochemical study and northern blot analysis.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions.Bioactive materials · 2022Article
- TGFα expression in myeloid malignancies.Journal of clinical pathology · 2016Article
- Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats.International journal of colorectal disease · 2010Article
- An in vitro model of epithelial cell growth stimulation in the rodent mammary gland.Cell proliferation · 2003Article
- Transforming growth factor-alpha precursors in human colon carcinoma cells.Digestive diseases and sciences · 2001Article
- Immunolocalization of transforming growth factor-alpha and epidermal growth factor receptor in the rat gastroduodenal area.Digestive diseases and sciences · 1999Article
- Expression of epidermal growth factor, transforming growth factor-alpha and their receptor in the human oesophagus.The Histochemical journal · 1997Article
- Species differences in the expression of transforming growth factor-alpha (TGF-alpha) in the submandibular gland and pancreas.International journal of pancreatology : official journal of the International Association of Pancreatology · 1997Article
- Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas.Japanese journal of cancer research : Gann · 1997Article
- Altered microsatellites in incomplete-type intestinal metaplasia adjacent to primary gastric cancers.Journal of clinical pathology · 1997Article
- Immunocytochemical expression of growth factors by odontogenic jaw cysts.Molecular pathology : MP · 1997Article
- Expression of cyclin E in colorectal adenomas and adenocarcinomas: correlation with expression of Ki-67 antigen and p53 protein.Virchows Archiv : an international journal of pathology · 1996Article
- Up-regulated expression of transforming growth factor-alpha in the bronchiolar-alveolar duct regions of asbestos-exposed rats.The American journal of pathology · 1996Article
- Immunolocalization of transforming growth factor alpha in normal human tissues.Histochemistry and cell biology · 1996Article
- Article
- Inhibition of TGF-alpha gene expression by vitamin A in airway epithelium.The Journal of clinical investigation · 1996Article
- Frequent amplification of the cyclin E gene in human gastric carcinomas.Japanese journal of cancer research : Gann · 1995Article
- Increased susceptibility to N-nitrosomethylurea gastric carcinogenesis in transforming growth factor alpha transgenic mice with gastric hyperplasia.Japanese journal of cancer research : Gann · 1995Article
- Developmental expression of transforming growth factor-alpha and epidermal growth factor receptor proteins in the human pancreas and digestive tract.Cell and tissue research · 1994Article
- Expression of transforming growth factor-alpha and its receptor during human liver development and maturation.Virchows Archiv : an international journal of pathology · 1994Article
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The expression of transforming growth factor alpha (TGF-alpha) was examined in various human tissues and the fetus, using immunohistochemistry and Northern blot analysis. TGF-alpha immunoreactivity was detected mainly in the epithelial cells of the digestive tract, liver, pancreas, kidney, thyroid, adrenal, skin, mammary gland and genital organs. In the digestive tract, epithelial cells with regenerative change or hyperplastic change showed strong immunoreactivity to TGF-alpha. Peripheral nerve, vessels, megakaryocytes and macrophages in the lung and spleen were also positive for TGF-alpha. By Northern blot analysis the expression of TGF-alpha mRNA was confirmed in the digestive tract, salivary gland, thyroid, kidney and mammary gland. In the human fetus, the nerve tissues, liver, adrenal and kidney were positive for TGF-alpha. Strong immunoreactivity to TGF-alpha was observed in the hepatocytes of the fetus. These findings indicate that TGF-alpha is produced by a variety of non-neoplastic cells in both adult and fetal tissues.
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