ReviewThe Journal of clinical investigation2003
Mechanisms for pituitary tumorigenesis: the plastic pituitary.
Review in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
177 citing papers in PubMed, 6 syntheses or guidelines pooled it, 416 citations in OpenAlex.
- The efficacy and safety of quinagolide in hyperprolactinemia treatment: A systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Double pituitary adenomas are most commonly associated with GH- and ACTH-secreting tumors: systematic review of the literature.Pituitary · 2017Pooled it
- Impact of gsp mutations in somatotroph pituitary adenomas on growth hormone response to somatostatin analogs: a meta-analysis.Pituitary · 2015Pooled it
- Silent corticotroph adenomas.Pituitary · 2015Pooled it
- Correlations of pituitary tumor transforming gene expression with human pituitary adenomas: a meta-analysis.PloS one · 2014Pooled it
- Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of giant pituitary adenomas.Pituitary · 2012Pooled it
- Trial
- GATA3-positive silent corticotroph adenomas are characterized by large size and massive infrasellar invasion.Pituitary · 2026Article
- Co-secretion of growth hormone and prolactin defines a high-risk acromegaly phenotype.Pituitary · 2026Article
- Article
- Challenging the known: unusual case report of acromegaly and subclinical Cushing's disease combination.AME case reports · 2026Article
- The Emerging Role of Prolactin as a Biomarker for Reproduction, Health, and Welfare in Wildlife Species: Elephants as a Model.Advances in experimental medicine and biology · 2026Review
- The clinical effects of miR-26a, miR-16, let-7, miR-128a and miR-223 in acromegaly.Irish journal of medical science · 2025Article
- NMR-Based Metabolomic Profiling for Brain Cancer Diagnosis and Treatment Guidance.Metabolites · 2025Review
- Prolactin serum concentrations in childhood-onset craniopharyngioma patients.Journal of endocrinological investigation · 2025Observational
- Improving the radiological prediction of surgical resection of nonfunctioning pituitary adenomas.Journal of endocrinological investigation · 2025Review
- Clinical, Radiological and Hormonal Characteristics of Our Patients with Primary Empty Sella: A Single-Centre Experience.Sisli Etfal Hastanesi tip bulteni · 2025Article
- Spontaneous Cerebrospinal Fluid Rhinorrhea in Pre-operative Pituitary Adenoma: A Report of Two Cases.Cureus · 2024Article
- The diverging role of O-GlcNAc transferase in corticotroph and somatotroph adenomas.Pituitary · 2024Article
- Characteristics and treatment of a silent somatotroph tumor that had transformed to a functional type: a case report and literature review.Gland surgery · 2024Article
117 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid, adrenal, reproductive, and growth functions. The gland responds to complex central and peripheral signals by trophic hormone secretion and by undergoing reversible plastic changes in cell growth leading to hyperplasia, involution, or benign adenomas arising from functional pituitary cells. Discussed herein are the mechanisms underlying hereditary pituitary hypoplasia, reversible pituitary hyperplasia, excess hormone production, and tumor initiation and promotion associated with normal and abnormal pituitary differentiation in health and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.