ArticleNeurogenetics2004
Narrowing of the critical region in autosomal recessive spastic paraplegia linked to the SPG5 locus.
Article in Neurogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.Acta neuropathologica · 2013Review
- Two novel CYP7B1 mutations in Italian families with SPG5: a clinical and genetic study.Journal of neurology · 2009Article
- Analysis of CYP7B1 in non-consanguineous cases of hereditary spastic paraplegia.Neurogenetics · 2009Article
- Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration.American journal of human genetics · 2008Article
- Hereditary spastic paraplegia.Current neurology and neuroscience reports · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
Hereditary spastic paraplegias are neurodegenerative disorders characterized clinically by progressive spasticity of the lower limbs. They are inherited as autosomal dominant, autosomal recessive, and X-linked traits. Four Italian families with autosomal recessive pure spastic paraplegia are reported. We show evidence of linkage to the SPG5 locus on chromosome 8p and our data reduce the candidate interval for SPG5 to the11-cM interval spanned by D8S285 and D8S544. We also report the search for mutations in five genes located in the region and their exclusion as candidates for SPG5.
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Registered trials
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