ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2004
Medulloblastoma with extensive nodularity: a variant occurring in the very young-clinicopathological and immunohistochemical study of four cases.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 41 citations in OpenAlex.
- Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage.Nature communications · 2024Article
- Post-treatment maturation of medulloblastoma in children: two cases and a literature review.The Journal of international medical research · 2018Review
- Cerebellopontine angle medulloblastoma with extensive nodularity in a child: case report and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Neuroblastoma at the trigeminal nerve in a cynomolgus monkey (Macaca fascicularis).Journal of toxicologic pathology · 2016Article
- Molecular subgroups of medulloblastoma.Expert review of neurotherapeutics · 2012Review
- Magnetic resonance imaging spectrum of medulloblastoma.Neuroradiology · 2011Article
- Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior.Brain pathology (Zurich, Switzerland) · 2007Article
- Recent advances in embryonal tumours of the central nervous system.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2005Review
- Survivin, Survivin-2B, and Survivin-deItaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcome.British journal of cancer · 2005Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
case reportFour cases of medulloblastoma with extensive nodularity (MBEN) are described. The patients were 3 years of age or younger at diagnosis. Cranial CT scan disclosed multiple coalescing nodules with peculiar 'grape-like' architecture in three patients. A near total excision of the tumour was performed in all four patients. The patients are currently receiving radiation and chemotherapy. Histologically, the tumours were characterized by extreme nodularity with intranodular uniformity and low proliferative index. The internodular zones were extremely cellular, composed of undifferentiated, mitotically active cells. Bcl-2 protein expression was observed in the cellular zones but was distinctly absent within nodules. DISCUSSION: MBEN represents a variant that occurs in very young children but has a good prognosis. The favourable outcome is probably related to its spontaneous neurocytic differentiation. The pattern of Bcl-2 immunoreactivity in MBENs indicates that this protein could be a key player in the regulation of neuronal differentiation in medulloblastomas.
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