ArticleProceedings of the National Academy of Sciences of the United States of America2003
Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 93 citations in OpenAlex.
- Reflections and perspectives on epigenetically mediated biological control: compromises in cancer and skeletal pathology.Academia biology · 2025Article
- Maintaining Transcriptional Specificity Through Mitosis.Annual review of genomics and human genetics · 2022Review
- Function and regulation of transcription factors during mitosis-to-G1 transition.Open biology · 2022Review
- Article
- Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer.Genes, chromosomes & cancer · 2019Review
- Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes.Molecular cancer research : MCR · 2018Review
- Nuclear organization mediates cancer-compromised genetic and epigenetic control.Advances in biological regulation · 2018Review
- Mitotic Gene Bookmarking: An Epigenetic Mechanism for Coordination of Lineage Commitment, Cell Identity and Cell Growth.Advances in experimental medicine and biology · 2017Review
- Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network.Nature cell biology · 2016Article
- A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition.Genes & development · 2016Article
- Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells.Journal of cellular physiology · 2016Article
- Genome accessibility is widely preserved and locally modulated during mitosis.Genome research · 2015Article
- Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins.Oncotarget · 2015Article
- Bookmarking target genes in mitosis: a shared epigenetic trait of phenotypic transcription factors and oncogenes?Cancer research · 2014Review
- Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory.PloS one · 2014Article
- Targeting deregulated epigenetic control in cancer.Journal of cellular physiology · 2013Review
- Mitotic bookmarking by transcription factors.Epigenetics & chromatin · 2013Article
- Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.Cell cycle (Georgetown, Tex.) · 2013Article
- Article
- Bookmarking the genome: maintenance of epigenetic information.The Journal of biological chemistry · 2011Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Postmitotic gene expression requires restoration of nuclear organization and assembly of regulatory complexes. The hematopoietic and osteogenic Runx (Cbfa/AML) transcription factors are punctately organized in the interphase nucleus and provide a model for understanding the subnuclear organization of tissue-specific regulatory proteins after mitosis. Here we have used quantitative in situ immunofluorescence microscopy and quantitative image analysis to show that Runx factors undergo progressive changes in cellular localization during mitosis while retaining a punctate distribution. In comparison, the acetyl transferase p300 and acetylated histone H4 remain localized with DNA throughout mitosis while the RNA processing factor SC35 is excluded from mitotic chromatin. Subnuclear organization of Runx foci is completely restored in telophase, and Runx proteins are equally partitioned into progeny nuclei. In contrast, subnuclear organization of SC35 is restored subsequent to telophase. Our results show a sequential reorganization of Runx and its coregulatory proteins that precedes restoration of RNA processing speckles. Thus, mitotic partitioning and spatiotemporal reorganization of regulatory proteins together render progeny cells equivalently competent to support phenotypic gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.