ArticleLearning & memory (Cold Spring Harbor, N.Y.)
In vitro analog of classical conditioning of feeding behavior in aplysia.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis.The Biological bulletin · 2020Review
- Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia.Behavioural brain research · 2019Article
- cGMP mediates short- and long-term modulation of excitability in a decision-making neuron in Aplysia.Neuroscience letters · 2018Article
- Article
- A novel in vitro analog expressing learning-induced cellular correlates in distinct neural circuits.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Functional organization and adaptability of a decision-making network in aplysia.Frontiers in neuroscience · 2012Article
- Classical conditioning analog enhanced acetylcholine responses but reduced excitability of an identified neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Octopamine promotes rhythmicity but not synchrony in a bilateral pair of bursting motor neurons in the feeding circuit of Aplysia.The Journal of experimental biology · 2010Article
- Localization of biogenic amines in the foregut of Aplysia californica: catecholaminergic and serotonergic innervation.The Journal of comparative neurology · 2009Article
- Neural analog of arousal: persistent conditional activation of a feeding modulator by serotonergic initiators of locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Behavioral and in vitro correlates of compulsive-like food seeking induced by operant conditioning in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Operant conditioning of gill withdrawal in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Central localization of plasticity involved in appetitive conditioning in Lymnaea.Learning & memory (Cold Spring Harbor, N.Y.)Article
- Extending in vitro conditioning in Aplysia to analyze operant and classical processes in the same preparation.Learning & memory (Cold Spring Harbor, N.Y.)Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The feeding behavior of Aplysia californica can be classically conditioned using tactile stimulation of the lips as a conditioned stimulus (CS) and food as an unconditioned stimulus (US). Moreover, several neural correlates of classical conditioning have been identified. The present study extended previous work by developing an in vitro analog of classical conditioning and by investigating pairing-specific changes in neuronal and synaptic properties. The preparation consisted of the isolated cerebral and buccal ganglia. Electrical stimulation of a lip nerve (AT4) and a branch of the esophageal nerve (En2) served as the CS and US, respectively. Three protocols were used: paired, unpaired, and US alone. Only the paired protocol produced a significant increase in CS-evoked fictive feeding. At the cellular level, classical conditioning enhanced the magnitude of the CS-evoked synaptic input to pattern-initiating neuron B31/32. In addition, paired training enhanced both the magnitude of the CS-evoked synaptic input and the CS-evoked spike activity in command-like neuron CBI-2. The in vitro analog of classical conditioning reproduced all of the cellular changes that previously were identified following behavioral conditioning and has led to the identification of several new learning-related neural changes. In addition, the pairing-specific enhancement of the CS response in CBI-2 indicates that some aspects of associative plasticity may occur at the level of the cerebral sensory neurons.
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