ArticleThe Journal of cell biology2003
ADF/cofilin use an intrinsic mode of F-actin instability to disrupt actin filaments.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 101 citations in OpenAlex.
- Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.The Journal of cell biology · 2026Article
- Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Global treadmilling coordinates actin turnover and controls the size of actin networks.Nature reviews. Molecular cell biology · 2017Review
- Actin-interacting Protein 1 Promotes Disassembly of Actin-depolymerizing Factor/Cofilin-bound Actin Filaments in a pH-dependent Manner.The Journal of biological chemistry · 2016Article
- Septin 9 Exhibits Polymorphic Binding to F-Actin and Inhibits Myosin and Cofilin Activity.Journal of molecular biology · 2015Article
- Metavinculin Tunes the Flexibility and the Architecture of Vinculin-Induced Bundles of Actin Filaments.Journal of molecular biology · 2015Article
- Single-molecule imaging and kinetic analysis of cooperative cofilin-actin filament interactions.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Coordination of the filament stabilizing versus destabilizing activities of cofilin through its secondary binding site on actin.Cytoskeleton (Hoboken, N.J.) · 2014Article
- Cofilin-induced changes in F-actin detected via cross-linking with benzophenone-4-maleimide.Biochemistry · 2013Article
- Importance of a Lys113-Glu195 intermonomer ionic bond in F-actin stabilization and regulation by yeast formins Bni1p and Bnr1p.The Journal of biological chemistry · 2013Article
- GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism.Current biology : CB · 2013Article
- Biophysics of actin filament severing by cofilin.FEBS letters · 2013Review
- Molecular origins of cofilin-linked changes in actin filament mechanics.Journal of molecular biology · 2013Article
- Myosin and tropomyosin stabilize the conformation of formin-nucleated actin filaments.The Journal of biological chemistry · 2012Article
- Cofilin 1-mediated biphasic F-actin dynamics of neuronal cells affect herpes simplex virus 1 infection and replication.Journal of virology · 2012Article
- Remodeling of actin filaments by ADF/cofilin proteins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The interaction of cofilin with the actin filament.Journal of molecular biology · 2011Article
- Cofilin cooperates with fascin to disassemble filopodial actin filaments.Journal of cell science · 2011Article
- The N-terminal domains of myosin binding protein C can bind polymorphically to F-actin.Journal of molecular biology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Proteins in the ADF/cofilin (AC) family are essential for rapid rearrangements of cellular actin structures. They have been shown to be active in both the severing and depolymerization of actin filaments in vitro, but the detailed mechanism of action is not known. Under in vitro conditions, subunits in the actin filament can treadmill; with the hydrolysis of ATP driving the addition of subunits at one end of the filament and loss of subunits from the opposite end. We have used electron microscopy and image analysis to show that AC molecules effectively disrupt one of the longitudinal contacts between protomers within one helical strand of F-actin. We show that in the absence of any AC proteins, this same longitudinal contact between actin protomers is disrupted at the depolymerizing (pointed) end of actin filaments but is prominent at the polymerizing (barbed) end. We suggest that AC proteins use an intrinsic mechanism of F-actin's internal instability to depolymerize/sever actin filaments in the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.