ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Activity-dependent feedforward inhibition modulates synaptic transmission in a spinal locomotor network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Feedforward discharges couple the singing central pattern generator and ventilation central pattern generator in the cricket abdominal central nervous system.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord.Nature communications · 2019Article
- Article
- The Lesioned Spinal Cord Is a "New" Spinal Cord: Evidence from Functional Changes after Spinal Injury in Lamprey.Frontiers in neural circuits · 2017Review
- Short-Term Synaptic Plasticity at Interneuronal Synapses Could Sculpt Rhythmic Motor Patterns.Frontiers in neural circuits · 2016Article
- Divisive gain modulation of motoneurons by inhibition optimizes muscular control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Changes in functional properties and 5-HT modulation above and below a spinal transection in lamprey.Frontiers in neural circuits · 2014Article
- Manipulations of spinal cord excitability evoke developmentally-dependent compensatory changes in the lamprey spinal cord.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Peptide neuromodulation of synaptic dynamics in an oscillatory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Identification of a cholinergic modulatory and rhythmogenic mechanism within the lamprey respiratory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Interplay between neuromodulator-induced switching of short-term plasticity at sensorimotor synapses in the neonatal rat spinal cord.The Journal of physiology · 2008Article
- Complexities and uncertainties of neuronal network function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- The action of spike frequency adaptation in the postural motoneurons of hermit crab abdomen during the first phase of reflex activation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2005Article
- Primitive roles for inhibitory interneurons in developing frog spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The analysis of synaptic properties in neural networks has focused on the properties of individual synapses. As a result, little is known of how neural assemblies arise from the connectivity and functional properties of different classes of network neurons. I examined synaptic properties in the lamprey locomotor network. Here I show that, in addition to their monosynaptic inputs to motor neurons, a proportion of the excitatory network interneurons (EINs) evoke an activity-dependent disynaptic feedforward inhibitory input. Connections from the excitatory interneurons to small ipsilateral inhibitory interneurons were found that could account for the feedforward inhibition. Both synapses in the disynaptic pathway exhibited activity-dependent facilitation during physiologically relevant spike trains, which could contribute to the delayed, activity-dependent development of the feedforward IPSP. Although it was not as common as the feedforward inhibition, the excitatory interneurons could also evoke feedforward excitatory inputs in motor neurons. EIN inputs to motor neurons usually depress during spike trains. In connections in which a delayed IPSP occurred, blocking the feedforward inhibition in motor neurons or preventing the activation of the disynaptic pathway abolished the depression of the direct EPSP during the spike train and could reveal an underlying facilitation. The feedforward inhibition thus heterosynaptically depressed the direct excitatory input to motor neurons. Activity-dependent heterosynaptic effects acting within network cellular assemblies can thus influence the integration of synaptic inputs in motor neurons. This could help to terminate ipsilateral motor neuron spiking during network activity.
Indexed as
Identifiers
14657166PMC6741052W2140356370What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.