ArticleThe EMBO journal2003
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 125 citations in OpenAlex.
- Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice.Nature communications · 2025Article
- The partitioning of TCR repertoires by thymic selection.The Journal of experimental medicine · 2024Review
- Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma.Epigenetics · 2023Article
- A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection.iScience · 2023Article
- Identification and Interpretation of eQTL and eGenes for Hodgkin Lymphoma Susceptibility.Genes · 2023Article
- Microbiota Ecosystem in Recurrent Cystitis and the Immunological Microenvironment of Urothelium.Healthcare (Basel, Switzerland) · 2023Review
- Application of ATAC-seq in tumor-specific T cell exhaustion.Cancer gene therapy · 2023Review
- Comparison Between Nr4a Transcription Factor Regulation and Function in Lymphoid and Tumor Treg Cells.Frontiers in immunology · 2022Review
- Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey.Nature reviews. Immunology · 2021Review
- Bladder Exposure toFrontiers in cellular and infection microbiology · 2021Article
- 'Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity.European journal of immunology · 2020Review
- Deletion of theFrontiers in genetics · 2020Article
- Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology.Frontiers in endocrinology · 2020Review
- Cancer Treatment Goes Viral: Using Viral Proteins to Induce Tumour-Specific Cell Death.Cancers · 2019Review
- Lnc-NA inhibits proliferation and metastasis in endometrioid endometrial carcinoma through regulation of NR4A1.Journal of cellular and molecular medicine · 2019Article
- Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.Cell reports · 2017Article
- Article
- The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3.Scientific reports · 2015Article
- Regulatory T-Cell Development in the Human Thymus.Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Nur77 is a nuclear orphan steroid receptor that has been implicated in negative selection. Expression of Nur77 in thymocytes and cell lines leads to apoptosis through a mechanism that remains unclear. In some cell lines, Nur77 was reported to act through a transcription-independent mechanism involving translocation to mitochondria, leading to cytochrome c release. However, we show here that Nur77-mediated apoptosis in thymocytes does not involve cytoplasmic cytochrome c release and cannot be rescued by Bcl-2. Microarray analysis shows that Nur77 induces many genes, including two novel genes (NDG1, NDG2) and known apoptotic genes FasL and TRAIL. Characterization of NDG1 and NDG2 indicates that NDG1 initiates a novel apoptotic pathway in a Bcl-2-independent manner. Thus Nur77-mediated apoptosis in T cells involves Bcl-2 independent transcriptional activation of several known and novel apoptotic pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.