ArticleGenome research2003
The clustered olfactory receptor gene family 262: genomic organization, promotor elements, and interacting transcription factors.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Determinants of odorant receptor transcription and gene choice.Chemical senses · 2025Review
- Regulatory Features for Odorant Receptor Genes in the Mouse Genome.Frontiers in genetics · 2017Review
- A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity.PLoS genetics · 2016Article
- Odorant Receptor Gene Choice.ChemoSense · 2015Article
- Sensational placodes: neurogenesis in the otic and olfactory systems.Developmental biology · 2014Review
- Differentiation of developing olfactory neurons analysed in terms of coupled epigenetic landscapes.Nucleic acids research · 2013Article
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- Article
- Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifs.BMC genomics · 2011Article
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- Achieving singularity in mammalian odorant receptor gene choice.Chemical senses · 2010Review
- Cloning and comparative analyses of the zebrafish Ugt repertoire reveal its evolutionary diversity.PloS one · 2010Article
- Mammalian olfactory receptors.Frontiers in cellular neuroscience · 2009Article
- Determination and functional analysis of the consensus binding site for TFII-I family member BEN, implicated in Williams-Beuren syndrome.The Journal of biological chemistry · 2008Article
- Identification of potential regulatory motifs in odorant receptor genes by analysis of promoter sequences.Genome research · 2006Article
- Global gene expression analyses of hematopoietic stem cell-like cell lines with inducible Lhx2 expression.BMC genomics · 2006Article
- Evolution of the "OR37" subfamily of olfactory receptors: a cross-species comparison.Journal of molecular evolution · 2006Article
- The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For six mouse olfactory receptor genes from family 262 which are expressed in clustered populations of olfactory sensory neurons, the genomic as well as cDNA structures were deciphered. All genes contained several exons which in some cases were alternatively spliced. Immediately upstream of the transcription start sites, sequence motif blocks were identified that are highly conserved among olfactory receptor (OR) genes which are expressed in clustered neuronal populations. By means of electrophoretic mobility shift assays, it was demonstrated that segments of the motif block region interact with proteins extracted from nuclear fractions of the olfactory epithelium. Yeast one-hybrid screenings of an olfactory cDNA library led to the identification of a set of transcription factors that specifically bind to particular elements of the motif block region. The identified factors can be categorized into two types: One group is known to be involved in transcriptional initiation, and the second group represents factors involved in pattern formations. The identified components may contribute to govern the precise topographic expression pattern of olfactory receptor genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.