Evidence map›Paper›PMID 14656836›Full record

SynthesisBMJ (Clinical research ed.)2003

Indirect comparison meta-analysis of aspirin therapy after coronary surgery.

Eric Lim, Ziad Ali, Ayyaz Ali, Tom Routledge, Lyn Edmonds, Douglas G Altman, Stephen Large

Erratum issuedOpen access · bronzeAbstract readComparative StudyMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Aspirin resistance - does it clinically matter?Clinical research in cardiology : official journal of the German Cardiac Society · 2006
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Eric LimDepartment of Cardiothoracic Surgery, Papworth Hospital, Cambridge CB3 8RE. eric.lim2@cvsnet.org
Ziad Ali
Ayyaz Ali
Tom Routledge
Lyn Edmonds
Douglas G Altman
Stephen Large
Papworth Hospital · GBCancer Research UK · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the efficacy of low and medium dose aspirin therapy after coronary surgery by using an indirect comparison meta-analysis. DATA SOURCES: Systematic literature search of Medline, Embase, Cochrane controlled trials register, and trial register sites on the internet. STUDY SELECTION: Outcome was evaluated by angiography and reported as graft occlusion and rate of events in patients. Trials that did not include aspirin as the sole therapy or did not have a placebo control arm were excluded. Articles were assessed for eligibility and quality and grouped according to dosage. The estimated difference in effect of low and medium dose aspirin on graft occlusion was obtained by combining the estimated log relative risks of low dose with placebo and medium dose with placebo.

resultsFor graft occlusion, the medium dose trials yielded a relative risk reduction of 45% compared with 26% for the low dose trials. The greater effect in the medium dose trials is summarised by a relative risk ratio of 0.74 (95% confidence interval 0.52 to 1.06; P = 0.10) for graft occlusion and 0.81 (0.57 to 1.16; P = 0.25) for events in patients.

conclusionsMedium dose aspirin may more successfully reduce graft occlusion than low dose regimens within the first year after coronary surgery.

Indexed as

Blood Vessel Prosthesis ImplantationAspirinCoronary DiseaseGraft Occlusion, VascularHumansPlatelet Aggregation InhibitorsPostoperative CareRandomized Controlled Trials as TopicRisk FactorsAspirinPlatelet Aggregation Inhibitors

Identifiers

PMID14656836
PMCPMC286307
OpenAlexW2126919236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.