ArticleDevelopment genes and evolution2004
Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family.
Article in Development genes and evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Review
- Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3.Cellular immunology · 2015Article
- Snail transcription factors in hematopoietic cell development: a model of functional redundancy.Experimental hematology · 2014Review
- Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency.PloS one · 2013Article
- Insights into the evolution of the snail superfamily from metazoan wide molecular phylogenies and expression data in annelids.BMC evolutionary biology · 2009Article
- Lamprey snail highlights conserved and novel patterning roles in vertebrate embryos.Development genes and evolution · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Snail genes comprise a family of zinc-finger transcription factor coding genes with multiple roles in early embryonic development of metazoans. The evolutionary history of this family has been studied in detail, revealing an initial duplication in Snail and Scratch genes preceding the protostome/deuterostome split, and posterior independent duplication events in the lineages leading to insects and vertebrates. The distribution of mammalian and teleost Snail genes fits with current models for whole genome duplication events at the base of the vertebrate lineage, plus an extra duplication in teleosts. However, two very divergent Snail genes, one from mammals and the other from teleost fishes, fit poorly into the phylogenetic analysis of the family. By means of database mining and synteny analysis, we provide evidence for these genes being orthologues, and evidence that they originated in an early duplication at the base of the vertebrates resulting in three and not two Snail genes. We further show that all three Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication.
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Registered trials
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