ArticleOncogene2003
Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- Voxel-based evidence of perfusion normalization in glioblastoma patients included in a phase I-II trial of radiotherapy/tipifarnib combination.Journal of neuro-oncology · 2015Trial
- Rho GTPases in cancer radiotherapy and metastasis.Cancer metastasis reviews · 2020Review
- Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies.ACS central science · 2020Article
- RhoB: Team Oncogene or Team Tumor Suppressor?Genes · 2018Review
- Behavioral remodeling of normal and cancerous epithelial cell lines with differing invasion potential induced by substrate elastic modulus.Cell adhesion & migration · 2018Article
- TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway.Oncotarget · 2016Article
- Cancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea Attention.Stem cells international · 2016Review
- Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities.Expert reviews in molecular medicine · 2015Review
- RhoB promotes γH2AX dephosphorylation and DNA double-strand break repair.Molecular and cellular biology · 2014Article
- RHOB influences lung adenocarcinoma metastasis and resistance in a host-sensitive manner.Molecular oncology · 2014Article
- Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Role of a DNA damage checkpoint pathway in ionizing radiation-induced glioblastoma cell migration and invasion.Cellular and molecular neurobiology · 2012Article
- Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.Cold Spring Harbor perspectives in medicine · 2012Review
- Normalization of the vasculature for treatment of cancer and other diseases.Physiological reviews · 2011Review
- Molecular targets for tumor radiosensitization.Chemical reviews · 2009Review
- The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells.Cancer research · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously demonstrated in vitro that inhibiting the biological pathways of the small GTPase Rho radiosensitizes the human glioma U87 cell line. The aim of this study was to determine if Rho might be involved in the control of in vivo radiosensitivity altogether by controlling cellular radioresistance and by modifying tumor microenvironment. We demonstrate here that the in vivo induction of the dominant negative of Rho, RhoBN19, in U87 xenografts induces a significant decrease of tumor cell survival after irradiation more important than the one we previously observed in vitro. This in vivo increased effect of RhoBN19 expression is due to the improvement of the tumor oxygenation associated with a significant decrease of the vessel density and of the metalloproteinase 2 (MMP2) expression. Moreover, in vitro RhoBN19 expression in U87 cells leads to the inhibition of MMP2 activity. Our results demonstrate for the first time that inhibiting Rho pathways modifies the in vivo radiosensitivity of human glioma cells by controlling intrinsic radioresistance, hypoxia and angiogenesis. These data strongly suggest that Rho should be a major determinant of cellular resistance to ionizing radiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.