Evidence map›Paper›PMID 1465443›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1992

Organization of the human skeletal myosin heavy chain gene cluster.

S J Yoon, S H Seiler, R Kucherlapati, L Leinwand

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 51 citations in OpenAlex.

  1. Characterization of the binding of skeletal muscle myosin to fibrin in trauma.The journal of trauma and acute care surgery · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.Proceedings of the National Academy of Sciences of the United States of America · 1999
    Article
  16. Article
  17. Isolation and localization of the skeletal myosin heavy chain 2X gene on pig chromosome 12q1.4-q1.5.Mammalian genome : official journal of the International Mammalian Genome Society · 1998
    Article
  18. A myosin family reunion.Journal of muscle research and cell motility · 1996
    Review
  19. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

S J YoonDepartment of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461.
S H Seiler
R Kucherlapati
L Leinwand
Albert Einstein College of Medicine · US

Funding

MYOSIN GENE DIVERSITY AND FUNCTIONR01GM029090 · NIGMS · YESHIVA UNIVERSITY · PI Leslie Anne Leinwand · 1985 to 2026
$12.3M
GENE REPLACEMENT IN MAMMALIAN CELLSR01GM033943 · NIGMS · YESHIVA UNIVERSITY · PI KUCHERLAPATI, RAJU S · 1985 to 1992
–
HUMAN GENOME DISSECTION BY HOMOLOGOUS RECOMBINATIONR01HG000380 · NHGRI · YESHIVA UNIVERSITY · PI KUCHERLAPATI, RAJU S · 1991 to 1993
–
NHGRI NIH HHS HG00380NIGMS NIH HHS GM29090NIGMS NIH HHS GM33943
6 · The paper itself

Abstract

Myosin is an important structural and enzymatic component of skeletal muscle. Multiple myosin isoforms are encoded by a multigene family and are expressed in different developmental stages and fiber types. In humans and mice, skeletal myosin heavy chain (MYH) genes are clustered on a single chromosome (17p and 11, respectively). Since the structural organization of the gene cluster may affect its expression as well as shed light on MYH genetic alterations, a physical map of the human MYH gene cluster was constructed. Nine yeast artificial chromosomes containing MYH genes were isolated and used to construct a contiguous set (contig) of overlapping yeast artificial chromosomes. This contig encompasses a genetic marker mapped to 17p13.1. Six MYH genes were located within a 500-kilobase segment of human DNA. The order of the genes within this cluster does not correspond to the developmental pattern of expression of individual members.

Indexed as

Base SequenceChromosome MappingCloning, MolecularGenesGenetic LinkageHumansMolecular Sequence DataMyosinsOligodeoxyribonucleotidesPolymerase Chain ReactionSaccharomyces cerevisiaeSequence Tagged SitesMyosinsOligodeoxyribonucleotides

Identifiers

PMID1465443
PMCPMC50701
OpenAlexW2081817284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.