ArticleProceedings of the National Academy of Sciences of the United States of America1992
Circadian oscillations in period gene mRNA levels are transcriptionally regulated.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed.
- Manganese Porphyrin Treatment Improves Redox Status Caused by Acute Compressive Spinal Cord Trauma.Antioxidants (Basel, Switzerland) · 2025Article
- Design Principles for Biological Adaptation: A Systems and Control-Theoretic Treatment.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping.International journal of molecular sciences · 2023Review
- Review
- Perfecting the Life Clock: The Journey from PTO to TTFL.International journal of molecular sciences · 2023Review
- Discovering design principles for biological functionalities:Perspectives from systems biology.Journal of biosciences · 2022Review
- Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.Cellular signalling · 2021Review
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- Circadian and Genetic Modulation of Visually-Guided Navigation in Drosophila Larvae.Scientific reports · 2020Article
- Aging and the clock: Perspective from flies to humans.The European journal of neuroscience · 2020Review
- Genome-wide circadian regulation: A unique system for computational biology.Computational and structural biotechnology journal · 2020Review
- Genetics of Circadian Rhythms.Neurologic clinics · 2019Review
- NewFrontiers in physiology · 2019Article
- Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior.Cold Spring Harbor perspectives in biology · 2018Review
- Reflections on contributing to "big discoveries" about the fly clock: Our fortunate paths as post-docs with 2017 Nobel laureates Jeff Hall, Michael Rosbash, and Mike Young.Neurobiology of sleep and circadian rhythms · 2018Review
- Biological Oscillators in Nanonetworks-Opportunities and Challenges.Sensors (Basel, Switzerland) · 2018Review
- Cardinal Epigenetic Role of non-coding Regulatory RNAs in Circadian Rhythm.Molecular neurobiology · 2018Review
- Circadian Etiology of Type 2 Diabetes Mellitus.Physiology (Bethesda, Md.) · 2018Review
- Biological clocks: their relevance to immune-allergic diseases.Clinical and molecular allergy : CMA · 2018Review
- A 50-Year Personal Journey: Location, Gene Expression, and Circadian Rhythms.Cold Spring Harbor perspectives in biology · 2017Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The period (per) gene is involved in regulating circadian rhythms in Drosophila melanogaster. The per gene is expressed in a circadian manner, where fluctuations in per mRNA abundance are influenced by its own translation product, which also cycles in abundance. Since per gene expression is necessary for circadian rhythmicity, we sought to determine how certain features of this feedback loop operate. The results of this study reveal that fluctuations in per mRNA are primarily controlled by fluctuations in per gene transcription, that per mRNA has a relatively short half-life, and that sequences sufficient to drive per mRNA cycling are present in 1.3 kilobases of 5' flanking sequences. These and other results indicate that the per feedback loop has all of the basic properties necessary to be a component of a circadian oscillator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.