ArticleParasitology research2004
A cysteine protease from Taenia solium metacestodes induce apoptosis in human CD4+ T-cells.
Article in Parasitology research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 48 citations in OpenAlex.
- Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction.Frontiers in immunology · 2025Article
- Ultrastructural changes in hydatid cyst walls obtained from human cases, exposed to different therapeutic approaches.Parasitology research · 2019Article
- Cysteine proteases as digestive enzymes in parasitic helminths.PLoS neglected tropical diseases · 2018Review
- The impact of anthelminthic therapeutics on serological and tissues apoptotic changes induced by experimental trichinosis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
- Soluble Fas/FasLare elevated in the serum and cerebrospinal fluid of patients with neurocysticercosis.Parasitology research · 2017Article
- Excretory-secretory product of third-stage Gnathostoma spinigerum larvae induces apoptosis in human peripheral blood mononuclear cells.Parasitology research · 2017Article
- Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR).Scientific reports · 2015Article
- Clinical symptoms, diagnosis, and treatment of neurocysticercosis.The Lancet. Neurology · 2014Review
- The study of apoptotic bifunctional effects in relationship between host and parasite in cystic echinococcosis: a new approach to suppression and survival of hydatid cyst.Parasitology research · 2012Article
- Neurocysticercosis: local and systemic immune-inflammatory features related to severity.Medical microbiology and immunology · 2012Article
- Decrease of peritoneal inflammatory CD4(+), CD8(+), CD19(+) lymphocytes and apoptosis of eosinophils in a murine Taenia crassiceps infection.Parasitology research · 2010Article
- Nitric oxide contributes to host resistance against experimental Taenia crassiceps cysticercosis.Parasitology research · 2007Article
- Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes.The Korean journal of parasitology · 2005Article
- The implantation of Taenia solium metacestodes in mice induces down-modulation of T-cell proliferation and cytokine production.Parasitology research · 2005Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Here we investigated whether the depletion of CD4+ lymphocytes, observed in mononuclear cells incubated with Taenia solium metacestode E/S products or with living cysts was due to apoptosis. Using the deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL), electron microscopy and DNA gel electrophoresis, we found signs of apoptosis in these cells. Results showed that cysteine protease activity was responsible for this effect, since E-64 prevented cell death in all cases. Electron microscopy studies showed that lymphocytes exhibited features of apoptosis such as cellular membrane integrity, strangling and fragmentation of nuclei, chromatin condensation, apoptotic bodies and loss of microvilli. In contrast, lymphocytes co-cultured with living metacestodes plus E-64 exhibited integrity of their structures. DNA fragmentation was detected by TUNEL assays and DNA gel electrophoresis. The results suggested that cell death induced by the cysteine protease from the T. solium metacestode may be involved in down-regulation of cell-mediated responses in infected hosts.
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