ReviewReproductive biology and endocrinology : RB&E2003
Immunology of term and preterm labor.
Review in Reproductive biology and endocrinology : RB&E, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 225 citations in OpenAlex.
- Preconception sleep, pregnancy loss, and adverse pregnancy outcomes among women with a history of pregnancy loss.Human reproduction (Oxford, England) · 2025Trial
- Transcriptome analysis of early pregnancy vitamin D status and spontaneous preterm birth.PloS one · 2020Trial
- Change in mononuclear leukocyte responsiveness in midpregnancy and subsequent preterm birth.Obstetrics and gynecology · 2013Trial
- Monocytes at the crossroads of inflammation and labor: biomarker potential in prolonged deliveries - a narrative review.Annals of medicine and surgery (2012) · 2025Article
- Chemokines in Pregnancy.Biomolecules · 2025Review
- Impact of Preterm Birth Subtype on Risk of Diagnosis of Autism Spectrum Disorders in the Offspring.Journal of autism and developmental disorders · 2025Article
- Cellular dynamics of cervical remodelling: insights from preterm and term labour.Archives of gynecology and obstetrics · 2025Observational
- Communication and Therapy Planning for Patients of Reproductive Age Under Immunomodulatory Treatments for Psoriasis or Psoriatic Arthritis-Survey of the German National Psoriasis Registry PsoBest.Healthcare (Basel, Switzerland) · 2025Article
- Climate change, evolution, and reproductive health: The impact of water insecurity and heat stress on pregnancy and lactation.Evolution, medicine, and public health · 2025Review
- Immunomodulatory dynamics in the porcine myometrium: global transcriptome analysis, including the effects of PPARγ ligands.BMC genomics · 2024Article
- Review
- C/EBPδ deficiency delays infection-induced preterm birth.BMC medicine · 2024Article
- Cord serum cytokines at birth and children's trajectories of mood dysregulation symptoms from 3 to 8 years: The EDEN birth cohort.Brain, behavior, & immunity - health · 2024Article
- Gestation-dependent increase in cervicovaginal pro-inflammatory cytokines and cervical extracellular matrix proteins is associated with spontaneous preterm delivery within 2 weeks of index assessment in South African women.Frontiers in immunology · 2024Article
- Minimal mRNA uptake and inflammatory response to COVID-19 mRNA vaccine exposure in human placental explants.iScience · 2023Article
- Integrating single-cell RNA sequencing with spatial transcriptomics reveals an immune landscape of human myometrium during labour.Clinical and translational medicine · 2023Article
- Minimal mRNA uptake and inflammatory response to COVID-19 mRNA vaccine exposure in human placental explants.medRxiv : the preprint server for health sciences · 2023Article
- Prostaglandin F2α requires activation of calcium-dependent signalling to trigger inflammation in human myometrium.Frontiers in endocrinology · 2023Article
- Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis.Frontiers in pediatrics · 2023Article
- Proteomic and miRNA Profiles of Exosomes Derived from Myometrial Tissue in Laboring Women.International journal of molecular sciences · 2022Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During pregnancy there is an alteration in maternal immunity within the uterus where innate, proinflammatory immune responses are tightly regulated to prevent immunological rejection of the fetal allograft. Disruption of the delicate balance of cytokines by bacteria or other factors increases the production of proinflammatory cytokines at the maternal-fetal interface and activates the parturition mechanism prematurely. Despite years of searching, there is still no broadly effective strategy for preventing preterm labor and most therapies are directed at inhibiting myometrial contractions and improving neonatal outcome. Recent studies with progestins and interleukin-10 (IL-10), however, are showing promise in randomized clinical trials and animal studies. Furthermore, the identification of the Toll-like receptors as upstream mediators of inflammation may offer alternative therapeutic targets for preventing this common pregnancy complication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.