ArticleNeurochemical research2003
Interaction between metals and chelating agents affects glutamate binding on brain synaptic membranes.
Article in Neurochemical research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Adverse health effects of emerging contaminants on inflammatory bowel disease.Frontiers in public health · 2023Review
- Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy.Molecules (Basel, Switzerland) · 2021Review
- Nanomotor-based adsorbent for blood Lead(II) removalBioactive materials · 2021Article
- Sulfhydryl groups as targets of mercury toxicity.Coordination chemistry reviews · 2020Article
- Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay.Biochimica et biophysica acta. General subjects · 2019Review
- A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment.Environmental science and pollution research international · 2016Review
- Oxidative stress in MeHg-induced neurotoxicity.Toxicology and applied pharmacology · 2011Review
- Toxicity biomarkers among US children compared to a similar cohort in France: a blinded study measuring urinary porphyrins.Toxicological and environmental chemistry · 2011Article
- Is dental amalgam safe for humans? The opinion of the scientific committee of the European Commission.Journal of occupational medicine and toxicology (London, England) · 2011Article
- Heavy metals modulate glutamatergic system in human platelets.Neurochemical research · 2007Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigates the possible effects of Hg2+, Pb2+, and Cd2+ on [3H]-glutamate binding. To better understand the role of the thiol-disulfide status on the toxicity of such metals toward glutamatergic neurotransmission, we used three thiol chelating agents, 2,3-dimercaptopropanol (BAL), 2,3-dimercaptopropane 1-sulfonate (DMPS), and meso-2,3-dimercaptosuccinic acid (DMSA). Dithiotreitol (DTT) was tested for its ability to prevent metals-induced inhibition on [3H]-glutamate binding. Hg2+, Pb2+, and Cd2+ showed a concentration-dependent inhibition on [3H]-glutamate binding, and mercury was the most effective inhibitor. BAL did not prevent [3H]-glutamate binding inhibition by Hg2+, Cd2+, and Pb2+. However, DMPS and DMSA prevented the inhibition caused by Cd2+ and Pb2+, but not by Hg2+. DTT did not prevent the inhibition on [3H]-glutamate binding caused by 10 microM Hg2+. In contrast, it was able to partially prevent [3H]-glutamate binding inhibition caused by 40 microM Pb2+ and Cd2+. These results demonstrated that the heavy metals present an inhibitory effect on [3H]-glutamate binding. In addition, BAL was less effective to protect [3H]-glutamate binding inhibition caused by these metals than other chelating agents studied.
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