ArticleThe Journal of physiology1992
Membrane recapture and early triggered secretion from the newly formed endocytotic compartment in bovine chromaffin cells.
Article in The Journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- SIP30 involvement in vesicle exocytosis from PC12 cells.Biochemistry and biophysics reports · 2024Article
- Simultaneous detection of vesicular content and exocytotic release with two electrodes in and at a single cell.Chemical science · 2021Article
- Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.Comprehensive Physiology · 2019Article
- How intravesicular composition affects exocytosis.Pflugers Archiv : European journal of physiology · 2018Review
- Imaging the post-fusion release and capture of a vesicle membrane protein.Nature communications · 2012Article
- Intravesicular factors controlling exocytosis in chromaffin cells.Cellular and molecular neurobiology · 2010Article
- Rapid endocytosis and vesicle recycling in neuroendocrine cells.Cellular and molecular neurobiology · 2010Review
- Suppression of Ca2+ syntillas increases spontaneous exocytosis in mouse adrenal chromaffin cells.The Journal of general physiology · 2009Article
- Activity-dependent differential transmitter release in mouse adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Secretagogue-triggered transfer of membrane proteins from neuroendocrine secretory granules to synaptic-like microvesicles.Molecular biology of the cell · 1999Article
- A complex web of signal-dependent trafficking underlies the triorganellar distribution of P-selectin in neuroendocrine PC12 cells.The Journal of cell biology · 1999Article
- Simultaneous capacitance and amperometric measurements of exocytosis: a comparison.Biophysical journal · 1996Article
- Rapid endocytosis coupled to exocytosis in adrenal chromaffin cells involves Ca2+, GTP, and dynamin but not clathrin.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Fast exocytosis and endocytosis triggered by depolarisation in single adrenal chromaffin cells before rapid Ca2+ current run-down.Pflugers Archiv : European journal of physiology · 1995Article
- A two-step model of secretion control in neuroendocrine cells.Pflugers Archiv : European journal of physiology · 1993Article
- Triggered exocytosis and endocytosis have different requirements for calcium and nucleotides in permeabilized bovine chromaffin cells.The Journal of membrane biology · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. Recycling of secretory vesicles in cultured bovine adrenal medullary cells was investigated. 2. Extracellular horseradish peroxidase (HRP), a fluid phase marker, was taken up into cultured adrenal medullary cells following carbamylcholine-induced secretion of catecholamine. 3. The endocytosed HRP remained compartmentalized within the cell, migrating to a low density band on a Percoll density gradient. The endocytotic compartment was distinct from the major pool of catecholamine-containing chromaffin granules, which were found at much higher densities on the Percoll gradient. 4. The chromaffin granule membrane marker dopamine beta-hydroxylase was associated with the endocytosed HRP compartment as well as with the heavier chromaffin granules. 5. A subsequent challenge of the cells with carbamylcholine triggered the release of up to forty per cent of the endocytosed HRP. 6. The time course for secretion of the fluid phase marker was similar to that for catecholamine secretion. 7. Triggered release of HRP was dependent on extracellular calcium. The dependence on the extracellular calcium concentration was similar to that of catecholamine release. 8. Release of HRP could be triggered from electropermeabilized cells by raising the intracellular Ca2+ into the micromolar range. The intracellular Ca2+ dependence of triggered HRP release was similar to that for catecholamine release. 9. HRP could be secreted as early as 5 min, and as late as 2 h after endocytosis. 10. These data provide evidence that endocytotic vesicles can rapidly re-enter the secretory cycle. Endocytosed vesicles may therefore not have to recycle via the trans-Golgi reticulum to form high-density chromaffin granules in order to re-enter the regulated secretory pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.