ArticleVirchows Archiv : an international journal of pathology2004
Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas.
Article in Virchows Archiv : an international journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 99 citations in OpenAlex.
- Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer.Cellular oncology (Dordrecht, Netherlands) · 2022Review
- Endogenous Pancreatic β Cell Regeneration: A Potential Strategy for the Recovery of β Cell Deficiency in Diabetes.Frontiers in endocrinology · 2019Review
- Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes.Cell metabolism · 2018Review
- Article
- Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.World journal of diabetes · 2014Review
- No evidence for β cell neogenesis in murine adult pancreas.The Journal of clinical investigation · 2013Article
- Current status of regeneration of pancreatic β-cells.Journal of diabetes investigation · 2013Review
- Article
- Histopathological changes in the pancreas from a spontaneous hyperglycemic cynomolgus monkey.Journal of toxicologic pathology · 2012Article
- A case of cellular alchemy: lineage reprogramming and its potential in regenerative medicine.Journal of molecular cell biology · 2012Review
- Acinar-to-ductal metaplasia induced by adenovirus-mediated pancreatic expression of Isl1.PloS one · 2012Article
- Islet neogenesis: a possible pathway for beta-cell replenishment.The review of diabetic studies : RDS · 2012Review
- β-Cell Generation: Can Rodent Studies Be Translated to Humans?Journal of transplantation · 2011Article
- Review
- Pancreatic beta-cells: from generation to regeneration.Seminars in cell & developmental biology · 2010Review
- Evidence for epithelial-mesenchymal transition in adult human pancreatic exocrine cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Minireview: beta-cell replacement therapy for diabetes in the 21st century: manipulation of cell fate by directed differentiation.Molecular endocrinology (Baltimore, Md.) · 2010Review
- Pancreatic stem/progenitor cells for the treatment of diabetes.The review of diabetic studies : RDS · 2010Review
- Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration.The review of diabetic studies : RDS · 2010Review
- Recent advances in stem cell research for the treatment of diabetes.World journal of stem cells · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injured pancreatic tissue, for example, after duct ligation, undergoes remodeling, which involves the replacement of exocrine acini by duct-like structures. This acinoductal metaplasia is probably at least partly due to transdifferentiation of amylase-positive, cytokeratin-20 (CK20)-negative acinar cells into amylase-negative, CK20-positive duct-like cells. Due to the kinetics of these phenotypic changes, however, it has not been possible to demonstrate transitional stages of differentiation, which would express both markers at the same time. We took advantage of the fact that dexamethasone treatment inhibits the loss of amylase from acinar cells to demonstrate transitional cells co-expressing amylase and CK20. This was found both in vivo, where duct-ligation induced metaplasia, and in vitro, after isolation of acini. In addition, we found evidence for an acinar-to-islet conversion under the form of transitional cells co-expressing amylase and insulin. These observations strengthen the notion that fully differentiated cells, such as exocrine pancreatic cells, retain the capacity to undergo important phenotypic switches. This finding could have applications in tissue engineering or cell replacement strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.