ArticlePflugers Archiv : European journal of physiology2004
In skeletal muscle the relaxation of the resting membrane potential induced by K(+) permeability changes depends on Cl(-) transport.
Article in Pflugers Archiv : European journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- Exercise and fatigue: integrating the role of KEuropean journal of applied physiology · 2023Review
- A four-electrode method to study dynamics of ion activity and transport in skeletal muscle fibers.The Journal of general physiology · 2019Article
- Elevation of extracellular osmolarity improves signs of myotonia congenita in vitro: a preclinical animal study.The Journal of physiology · 2019Article
- Osmosensation in TRPV2 dominant negative expressing skeletal muscle fibres.The Journal of physiology · 2015Article
- Properties of single FDB fibers following a collagenase digestion for studying contractility, fatigue, and pCa-sarcomere shortening relationship.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Changes in myoplasmic Ca2+ during fatigue differ between FDB fibers, between glibenclamide-exposed and Kir6.2-/- fibers and are further modulated by verapamil.Physiological reports · 2015Article
- Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia.Journal of biomedicine & biotechnology · 2011Review
- DHPR activation underlies SR Ca2+ release induced by osmotic stress in isolated rat skeletal muscle fibers.The Journal of general physiology · 2009Article
- Gating pore currents in DIIS4 mutations of NaV1.4 associated with periodic paralysis: saturation of ion flux and implications for disease pathogenesis.The Journal of general physiology · 2008Article
- Effect of repetitive stimulation on cell volume and its relationship to membrane potential in amphibian skeletal muscle.Pflugers Archiv : European journal of physiology · 2006Article
- The effect of intracellular acidification on the relationship between cell volume and membrane potential in amphibian skeletal muscle.The Journal of physiology · 2005Article
- A quantitative analysis of cell volume and resting potential determination and regulation in excitable cells.The Journal of physiology · 2004Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
In resting skeletal muscle the potassium permeability is determined by the permeability of the inwardly potassium rectifier. Continuous resting membrane potential measurements are done to follow the relaxation of the membrane potential upon changes in potassium permeability. Inhibition of the inwardly potassium rectifier, by extracellular application of 80 microM Ba(2+), causes the cell to depolarize with mean time constants as follows: in control 127+/-7 s ( n=23), in the presence of bumetanide, as an inhibitor of the Na(+)/K(+)/2Cl(-) cotransporter, 182+/-23 s ( n=7), in hypertonic media (340 mosmol/kg) 90.4+/-5 s ( n=7) and in reduced chloride medium 64+/-8 s ( n=5). The depolarizing relaxation of the membrane potential induced by reduction of extracellular potassium produces similar results. These time constants are at least three orders of magnitude slower than the time constants reported in the literature for the inhibition of the inwardly potassium rectifier. Chloride transport affects the relaxation of the membrane potential. A further characterization of chloride transport is done by following the relaxation of the membrane potential upon application of chloride transport modulators. It is argued that the electroneutral cotransporter, for which a flux was preliminarily estimated of 13.4 pmol cm(-2) s(-1), has a considerable role in the processes related to the resting membrane potential.
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