ArticleOncogene2004
IFNgamma sensitization to TRAIL-induced apoptosis in human thyroid carcinoma cells by upregulating Bak expression.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- 10-HDA Induces ROS-Mediated Apoptosis in A549 Human Lung Cancer Cells by Regulating the MAPK, STAT3, NF-BioMed research international · 2020Article
- Overexpression of BID in thyroids of transgenic mice increases sensitivity to iodine-induced autoimmune thyroiditis.Journal of translational medicine · 2014Article
- Soypeptide lunasin in cytokine immunotherapy for lymphoma.Cancer immunology, immunotherapy : CII · 2014Article
- Down-modulation of expression, or dephosphorylation, of IG20/MADD in tumor necrosis factor-related apoptosis-inducing ligand-resistant thyroid cancer cells makes them susceptible to treatment with this ligand.Thyroid : official journal of the American Thyroid Association · 2013Article
- Article
- Common genetic variants related to genomic integrity and risk of papillary thyroid cancer.Carcinogenesis · 2011Article
- A critical role of TRAIL expressed on cotransplanted hepatic stellate cells in prevention of islet allograft rejection.Microsurgery · 2010Article
- Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin.Experimental & molecular medicine · 2009Article
- A critical role for TRAIL in resolution of granulomatous experimental autoimmune thyroiditis.The Journal of pathology · 2008Article
- Article
- Mast cells dysregulate apoptotic and cell cycle genes in mucosal squamous cell carcinoma.Cancer cell international · 2006Article
- Interferons alpha and gamma induce p53-dependent and p53-independent apoptosis, respectively.Oncogene · 2005Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
TRAIL preferentially induces apoptosis in tumor cells and virus-infected cells. Unlike other tumor necrosis factor family members, TRAIL does not kill cells from most normal tissues and has thus been proposed as a promising new cancer treatment. Our study demonstrated that IFNgamma combined with TRAIL can trigger apoptosis in vitro in several resistant thyroid tumor cell lines, such as thyroid anaplastic carcinoma cells (ARO cells), while either agent alone exerts only a minimal effect. We further tested this effect on a mouse thyroid tumor model, when in vivo tumor growth was also significantly inhibited by this combination. The mechanism of how IFNgamma sensitized thyroid carcinoma cells to TRAIL-induced apoptosis was investigated by screening global gene alterations in ARO cells treated with IFNgamma. Microarray data revealed that a proapoptotic gene, Bak, is markedly upregulated by IFNgamma, and this was confirmed by RNase protection assay. Western blot analysis also showed a significant increase in Bak at the protein level. Upregulation of Bak and sensitization for apoptosis by IFNgamma was blocked by overexpression of antisense Bak in ARO cells. Furthermore, overexpression of Bak sensitized ARO cell to TRAIL-induced apoptosis without the need for IFNgamma pretreatment. This suggests that Bak is a regulatory molecule involved in IFNgamma-facilitated TRAIL-mediated apoptosis in thyroid cancer cells.
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