ArticleMolecular psychiatry2003
Antipsychotic drug treatment alters expression of mRNAs encoding lipid metabolism-related proteins.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Identifying serum lipidomic signatures related to prognosis in first-episode schizophrenia.BMC psychiatry · 2025Article
- Article
- Common changes in rat cortical gene expression after chronic treatment with chlorpromazine and haloperidol may be related to their antipsychotic efficacy.Neuroscience applied · 2023Article
- An Easy-to-Implement Hierarchical Standardization for Variable Selection under Strong Heredity Constraint.Journal of statistical theory and practice · 2020Article
- Clozapine-induced transcriptional changes in the zebrafish brain.NPJ schizophrenia · 2020Article
- Atypical Antipsychotics and the Human Skeletal Muscle Lipidome.Metabolites · 2018Article
- Subchronic olanzapine exposure leads to increased expression of myelination-related genes in rat fronto-medial cortex.Translational psychiatry · 2017Article
- Article
- Membrane lipidomics in schizophrenia patients: a correlational study with clinical and cognitive manifestations.Translational psychiatry · 2016Article
- Gene-expression analysis of clozapine treatment in whole blood of patients with psychosis.Psychiatric genetics · 2016Article
- Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [¹¹C]MP-10 PET rodent imaging study with ex vivo confirmation.Translational psychiatry · 2014Article
- Integrated approaches to understanding antipsychotic drug action at GPCRs.Current opinion in cell biology · 2014Review
- Inference of modules associated to eQTLs.Nucleic acids research · 2012Article
- α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2.Nature neuroscience · 2011Article
- Apolipoproteins in the brain: implications for neurological and psychiatric disorders.Clinical lipidology · 2010Article
- A role of apolipoprotein D in triglyceride metabolism.Journal of lipid research · 2010Article
- Apolipoprotein D: an overview of its role in aging and age-related diseases.Cell cycle (Georgetown, Tex.) · 2010Article
- Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging.Aging · 2009Review
- Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease.Neurochemical research · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Using an automated PCR-based genomics approach, TOtal Gene expression Analysis (TOGA), we have examined gene expression profiles of mouse striatum and frontal cortex in response to clozapine and haloperidol drug treatment. Of 17 315 mRNAs observed, TOGA identified several groups of related molecules that were regulated by drug treatment. The expression of some genes encoding proteins involved in neurotransmission, signal transduction, oxidative stress, cell adhesion, apoptosis and proteolysis were altered in the brains of both clozapine- and haloperidol-treated mice as recognized by TOGA. Most notable was the differential expression of those genes whose products are associated with lipid metabolism. These include apolipoprotein D (apoD), the mouse homolog of oxysterol-binding protein-like protein 8 (OSBPL8), a diacylglycerol receptor (n-chimerin), and lysophosphatidic acid (LPA) acyltransferase. Real-time PCR analysis confirmed increases in the RNA expression of apoD (1.6-2.2-fold) and OSBPL8 (1.7-2.6-fold), and decreases in the RNA expression of n-chimerin (1.5-2.2-fold) and LPA acyltransferase (1.5-fold) in response to haloperidol and/or clozapine treatment. Additional molecules related to calcium homeostasis and signal transduction, as well as four sequences of previously unidentified mRNAs, were also confirmed by real-time PCR to be regulated by drug treatment. While antipsychotic drugs may affect several metabolic pathways, lipid metabolism/signaling pathways may be of particular importance in the mechanisms of antipsychotic drug action and in the pathophysiology of psychiatric disorders.
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Registered trials
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