Trial reportEuropean journal of clinical nutrition2003
Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men.
Trial report in European journal of clinical nutrition, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Postprandial Fatty Acid Profile, but Not Cardiometabolic Risk Markers, Is Modulated by Dairy Fat Manipulation in Adults with Moderate Cardiovascular Disease Risk: The Randomized Controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) Study.The Journal of nutrition · 2021Trial
- Second meal effects of dietary calcium and vitamin D.European journal of clinical nutrition · 2008Trial
- Liver clock: Malalignment and entrainment therapeutics.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Characterisation of Fasting and Postprandial NMR Metabolites: Insights from the ZOE PREDICT 1 Study.Nutrients · 2023Article
- Circadian clock and temporal meal pattern.Medical review (2021) · 2023Review
- Eat, Train, Sleep-Retreat? Hormonal Interactions of Intermittent Fasting, Exercise and Circadian Rhythm.Biomolecules · 2021Review
- Time-of-Day-Dependent Physiological Responses to Meal and Exercise.Frontiers in nutrition · 2020Review
- Effects of time of feeding during gestation on sow's performance1.Journal of animal science · 2019Article
- Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men.Nature communications · 2017Article
- Physiological responses to food intake throughout the day.Nutrition research reviews · 2014Review
- Time-of-day and nutrient composition of eating occasions: prospective association with the metabolic syndrome in the 1946 British birth cohort.International journal of obesity (2005) · 2013Article
- Postprandial metabolism of meal triglyceride in humans.Biochimica et biophysica acta · 2012Review
- Assessing individual metabolic responsiveness to a lipid challenge using a targeted metabolomic approach.Metabolomics : Official journal of the Metabolomic Society · 2009Article
- Methodology for studying postprandial lipid metabolism.European journal of clinical nutrition · 2007Review
- The influence of walking performed immediately before meals with moderate fat content on postprandial lipemia.Lipids in health and disease · 2005Article
- Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm.EMBO reports · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether the postprandial changes in plasma triacylglycerol (TAG), nonesterified fatty acids (NEFA), glucose and insulin concentrations in young men were the same if an identical meal was fed at breakfast and lunch, and if the response to lunch was modified by consumption of breakfast.
methodsIn two trials (1 and 2) healthy subjects (age 22+/-1 y, body mass index 22+/-2 kg/m(2)) were fed the same mixed macronutrient meal at breakfast at 08:00 h and lunch at 14:00 h. In the third trial, no breakfast was fed and the overnight fast extended until lunch at 14:00 h. Addition of [1,1,1-(13)C]tripalmitin to one meal in each trial was used to distinguish between endogenous and meal-derived lipids.
resultsThe postprandial changes in TAG, NEFA and glucose concentrations were similar in trials 1 and 2. The change in plasma total TAG concentration was about two fold less (P<0.05) after lunch compared to breakfast. Postprandial NEFA suppression was the same after breakfast and lunch. Glucose and insulin responses were significantly greater following lunch suggesting decreasing insulin sensitivity during the day. Consumption of breakfast did not alter the postprandial total TAG or NEFA responses after lunch. Measurement of [(13)C]palmitic acid concentration showed that handling of TAG and NEFA from the meal was the same after breakfast and lunch, and was not altered by consumption of breakfast.
conclusionsOverall, these data suggest that in young, healthy men regulation of plasma TAG from endogenous sources, principally VLDL, but not chylomicrons during the postprandial period leads to differences in the magnitude of lipaemic response when the same meal was consumed at breakfast or at lunch 6 h later.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.