ArticleBritish journal of cancer2003
Matrix metalloproteinase-7 and matrix metalloproteinase-9 are associated with unfavourable prognosis in superficial oesophageal cancer.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis.Drug design, development and therapy · 2015Pooled it
- Prognostic value of matrix metalloproteinase-7 expression in patients with non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Article
- Drug repositioning for esophageal squamous cell carcinoma.Frontiers in genetics · 2022Article
- Lower Serum Matrix Metalloproteinase‑9 in Metastatic Patients with Esophageal Squamous Cell Carcinoma After Concurrent Radiotherapy Was Significant for Prognosis.OncoTargets and therapy · 2020Article
- Silencing microRNA-330-5p increases MMP1 expression and promotes an invasive phenotype in oesophageal adenocarcinoma.BMC cancer · 2019Article
- Amperometric Biosensor of Matrix Metalloproteinase-7 Enhanced by Pd-Functionalized Carbon Nanocomposites.Nanoscale research letters · 2018Article
- Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance.Physiological reports · 2018Article
- Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway.Cytotechnology · 2018Article
- Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer.Scientific reports · 2016Article
- XBP1 induces MMP-9 expression to promote proliferation and invasion in human esophageal squamous cell carcinoma.American journal of cancer research · 2016Article
- Sensitive surface enhanced Raman scattering multiplexed detection of matrix metalloproteinase 2 and 7 cancer markers.Biomedical optics express · 2015Article
- Matrix metalloproteinase 1, 3, and 9 polymorphisms and esophageal squamous cell carcinoma risk.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Gelatinase B (-1562C/T) polymorphism in tumor progression and invasion of breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- High expression of matrix metalloproteinase-9 indicates poor prognosis in human hilar cholangiocarcinoma.International journal of clinical and experimental pathology · 2014Article
- Clinicopathological and prognostic role of MMP-9 in esophageal squamous cell carcinoma: a meta-analysis.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013Article
- Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma.International journal of cancer · 2012Article
- mRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma.British journal of cancer · 2012Article
- Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma.Journal of cancer research and clinical oncology · 2012Article
- Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer.World journal of gastrointestinal oncology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
If oesophageal carcinoma is detected in the superficial stage, the prognosis is better than for advanced oesophageal carcinoma. But the factors which predict the prognosis and treatment policy remain unclear. Matrix metalloproteinase-7 (MMP-7) and matrix metalloproteinase-9 (MMP-9) have been reported to have close associations with tumour invasion and metastasis. In this study, we retrospectively studied the relations between MMP-7 and MMP-9 expression in immunohistochemistry, clinicopathologic factors, and prognosis in 55 superficial oesophageal carcinomas. MMP-7 and MMP-9 expression occurred in 23.6% and 47.3% of the patients, respectively. MMP-7 expression was significantly correlated with the presence of nodal metastasis (P=0.004). MMP-9 expression was significantly correlated with the depth of tumour invasion (P=0.004), lymphatic permeation (P=0.001), nodal metastasis (P=0.049), and pathologic differentiation grade (P=0.003). By the log-rank test, MMP-7 expression and MMP-9 expression on the invasive front were related to the prognosis. In multivariate analysis, MMP-9 expression on the invasive front was an independent prognostic indicator. The combined expression of MMP-7 and MMP-9 may be a good marker for the degree of malignancy of oesophageal cancer and for the presence of lymphatic metastasis.
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