ArticleMolecular pathology : MP2003
Nuclear beta catenin as a potential prognostic and diagnostic marker in patients with colorectal cancer from Hong Kong.
Article in Molecular pathology : MP, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Association ofGenetics research · 2022Pooled it
- Pooled it
- Evaluation of β-catenin Expression by Immunohistochemistry in Colorectal Adenoma and Carcinoma and its Correlation with Pathological Prognostic Factors.Iranian journal of pathology · 2026Article
- Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin.Cell communication and signaling : CCS · 2021Article
- Characterization of LGR5 expression in poorly differentiated colorectal carcinoma with mismatch repair protein deficiency.BMC cancer · 2020Article
- NAP1L1: A Novel Human Colorectal Cancer Biomarker Derived From Animal Models ofFrontiers in oncology · 2020Article
- MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure.Science advances · 2019Article
- Profiles of Radioresistance Mechanisms in Prostate Cancer.Critical reviews in oncogenesis · 2018Review
- Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation.Oncotarget · 2017Article
- The different pathogeneses of sporadic adenoma and adenocarcinoma in non-ampullary lesions of the proximal and distal duodenum.Oncotarget · 2017Article
- Comparison of biomarker expression between proximal and distal colorectal adenomas: The Tennessee-Indiana Adenoma Recurrence Study.Molecular carcinogenesis · 2017Article
- Inhibition of human telomerase reverse transcriptase in vivo and in vitro for retroviral vector-based antisense oligonucleotide therapy in ovarian cancer.Cancer gene therapy · 2016Article
- Prognostic Significance of Nuclear β-Catenin Expression in Patients with Colorectal Cancer from Iran.Iranian Red Crescent medical journal · 2015Article
- Dietary vitamin A regulates wingless-related MMTV integration site signaling to alter the hair cycle.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer.EMBO molecular medicine · 2013Article
- Investigation of β-catenin and E-cadherin expression in Dukes B2 stage colorectal cancer with tissue microarray method. Is it a marker of metastatic potential in rectal cancer?Pathology oncology research : POR · 2012Article
- SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer.BMC cancer · 2011Article
- Article
- Analysis of cell cycle-related proteins in gastric intramucosal differentiated-type cancers based on mucin phenotypes: a novel hypothesis of early gastric carcinogenesis based on mucin phenotype.BMC gastroenterology · 2010Article
- Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors.BMC cancer · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo study the expression of nuclear beta catenin in patients with colorectal cancer, colorectal adenoma, and colorectal polyps to elucidate its role in carcinogenesis, and its potential for prognosis and diagnosis.
methodsThe expression of nuclear beta catenin was studied by immunohistochemistry using paraffin wax embedded specimens. Sixty specimens each of colorectal carcinoma, colorectal adenoma, colorectal polyp, and normal colorectal specimens were analysed. The potential for prognosis was assessed by correlating nuclear beta catenin expression in 60 and 75 patients with colorectal cancer with lymph node metastasis and survival, respectively. The diagnostic capacity was explored by comparing nuclear beta catenin expression in 60 patients with colorectal cancer with other cytokeratin 20 (CK20) positive adenocarcinomas, namely: 30 colonic mucinous adenocarcinomas, 30 gastric adenocarcinomas, 27 pancreatic adenocarcinomas, and 12 ovarian mucinous adenocarcinomas.
resultsNuclear beta catenin expression was highly associated with progression of colorectal tissue from normal epithelial tissue, polyps, adenomas, to carcinomas (r = 0.875; p < 0.0001). Nineteen patients with colorectal adenoma who subsequently developed colorectal carcinoma had higher nuclear beta catenin expression than those with colorectal adenomas alone (p < 0.0001). Moreover, those patients with colorectal cancer and high nuclear beta catenin expression had a higher incidence of lymph node metastasis (chi(2) = 16.99; p < 0.005) and shorter overall survival (p < 0.0001). Finally, nuclear beta catenin expression in colorectal adenocarcinomas was significantly higher than in other CK20 positive adenocarcinomas.
conclusionsNuclear beta catenin expression is a potential prognostic factor in patients with colorectal cancer, and together with CK20, it could be used to identify colorectal carcinoma in the Hong Kong population.
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