ArticleMolecular and cellular biology2003
The c-myc insulator element and matrix attachment regions define the c-myc chromosomal domain.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 82 citations in OpenAlex.
- Loop stacking organizes genome folding from TADs to chromosomes.Molecular cell · 2023Article
- Induced hepatic stem cells maintain self-renewal through the high expression of Myc coregulated by TET1 and CTCF.Cell & bioscience · 2022Article
- Article
- A One-Step PCR-Based Assay to Evaluate the Efficiency and Precision of Genomic DNA-Editing Tools.Molecular therapy. Methods & clinical development · 2017Article
- Mice deficient ofeLife · 2017Article
- Cooverexpression of EpCAM and c-myc genes in malignant breast tumours.Journal of genetics · 2017Article
- A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation.Genes & development · 2015Article
- Poly(ADP-ribosyl)ation is required to modulate chromatin changes at c-MYC promoter during emergence from quiescence.PloS one · 2014Article
- TM6, a novel nuclear matrix attachment region, enhances its flanking gene expression through influencing their chromatin structure.Molecules and cells · 2013Article
- Proteomic profile identifies dysregulated pathways in Cornelia de Lange syndrome cells with distinct mutations in SMC1A and SMC3 genes.Journal of proteome research · 2012Article
- MyoD regulates p57kip2 expression by interacting with a distant cis-element and modifying a higher order chromatin structure.Nucleic acids research · 2012Article
- The insulator protein CTCF binding sites in the orf73/LANA promoter region of herpesvirus saimiri are involved in conferring episomal stability in latently infected human T cells.Journal of virology · 2012Article
- Comprehensive identification and annotation of cell type-specific and ubiquitous CTCF-binding sites in the human genome.PloS one · 2012Article
- Functional and molecular characterization of the role of CTCF in human embryonic stem cell biology.PloS one · 2012Article
- A cell cycle role for the epigenetic factor CTCF-L/BORIS.PloS one · 2012Article
- Mechanism of glycyrrhizic acid inhibition of Kaposi's sarcoma-associated herpesvirus: disruption of CTCF-cohesin-mediated RNA polymerase II pausing and sister chromatid cohesion.Journal of virology · 2011Article
- Allele-specific transcriptional elongation regulates monoallelic expression of the IGF2BP1 gene.Epigenetics & chromatin · 2011Article
- A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- CTCF regulates the local epigenetic state of ribosomal DNA repeats.Epigenetics & chromatin · 2010Article
- Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved.Developmental biology · 2010Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Insulator elements and matrix attachment regions are essential for the organization of genetic information within the nucleus. By comparing the pattern of histone modifications at the mouse and human c-myc alleles, we identified an evolutionarily conserved boundary at which the c-myc transcription unit is separated from the flanking condensed chromatin enriched in lysine 9-methylated histone H3. This region harbors the c-myc insulator element (MINE), which contains at least two physically separable, functional activities: enhancer-blocking activity and barrier activity. The enhancer-blocking activity is mediated by CTCF. Chromatin immunoprecipitation assays demonstrate that CTCF is constitutively bound at the insulator and at the promoter region independent of the transcriptional status of c-myc. This result supports an architectural role of CTCF rather than a regulatory role in transcription. An additional higher-order nuclear organization of the c-myc locus is provided by matrix attachment regions (MARs) that define a domain larger than 160 kb. The MARs of the c-myc domain do not act to prevent the association of flanking regions with lysine 9-methylated histones, suggesting that they do not function as barrier elements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.