ArticleMolecular and cellular biology2003
Global control of histone modification by the anaphase-promoting complex.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Targeting HDAC and proteostasis to eradicate quiescent cancer cells.Cancer gene therapy · 2026Article
- The Interplay between Dysregulated Metabolism and Epigenetics in Cancer.Biomolecules · 2023Review
- Article
- Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae.PLoS genetics · 2017Article
- Metabolic Signaling to Chromatin.Cold Spring Harbor perspectives in biology · 2016Review
- Prognostic implications of securin expression and sub-cellular localization in human breast cancer.Cellular oncology (Dordrecht, Netherlands) · 2016Article
- The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress.Nature cell biology · 2016Article
- Dispensability of the SAC Depends on the Time Window Required by Aurora B to Ensure Chromosome Biorientation.PloS one · 2015Article
- Protein acetylation and acetyl coenzyme a metabolism in budding yeast.Eukaryotic cell · 2014Review
- Histone hypoacetylation-activated genes are repressed by acetyl-CoA- and chromatin-mediated mechanism.Biochimica et biophysica acta · 2014Article
- The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle.Oncogene · 2014Article
- The yeast AMPK homolog SNF1 regulates acetyl coenzyme A homeostasis and histone acetylation.Molecular and cellular biology · 2013Article
- Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation.The Journal of biological chemistry · 2013Article
- Rpd3- and spt16-mediated nucleosome assembly and transcriptional regulation on yeast ribosomal DNA genes.Molecular and cellular biology · 2013Article
- Acetyl-CoA carboxylase regulates global histone acetylation.The Journal of biological chemistry · 2012Article
- Transcriptional regulation by Asf1: new mechanistic insights from studies of the DNA damage response to replication stress.The Journal of biological chemistry · 2011Article
- SWI/SNF and Asf1 independently promote derepression of the DNA damage response genes under conditions of replication stress.PloS one · 2011Article
- Transcriptional regulation in yeast during diauxic shift and stationary phase.Omics : a journal of integrative biology · 2010Review
- Asf1 can promote trimethylation of H3 K36 by Set2.Molecular and cellular biology · 2010Article
- A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA.Nucleic acids research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylation and phosphorylation of the amino-terminal tails of the core histones fluctuate on a global scale in concert with other major events in chromosome metabolism. A ubiquitin ligase, the anaphase-promoting complex (APC), controls events in chromosome metabolism such as sister chromatid cohesion and may regulate H3 phosphorylation by targeting Aurora A, one of several S10-directed H3 kinases in vertebrate cells, for destruction by the proteasome. Our analysis of apc10Delta and apc11(ts) loss-of-function mutants reveals that the APC controls the global level of H3 S10 phosphorylation in cycling yeast cells. Surprisingly, it also regulates dephosphorylation of H3 and global deacetylation of H2B, H3, and H4 during exit from the cell cycle into G(0). Genetic, biochemical, and microarray analyses suggest that APC-dependent cell cycle control of H3 phosphorylation is exerted at the level of an Aurora H3 kinase, Ipl1p, while APC-dependent transcriptional induction of GLC7, an essential H3 phosphatase, contributes to sustained H3 dephosphorylation upon cell cycle withdrawal. Collectively, our results establish that core histone acetylation state and H3 phosphorylation are physiologically regulated by the APC and suggest a model in which global reconfiguration of H3 phosphorylation state involves APC-dependent control of both an H3 kinase and a conserved phosphatase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.