ArticleMolecular and cellular biology2003
Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Roles of the NFI/CTF gene family in transcription and development: update 2025.Academia biology · 2025Article
- PIN1 is a novel interaction partner and a negative upstream regulator of the transcription factor NFIB.FEBS letters · 2024Article
- PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function.Nature communications · 2024Article
- PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function.bioRxiv : the preprint server for biology · 2023Article
- NK2 homeobox gene cluster: Functions and roles in human diseases.Genes & diseases · 2023Review
- FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma.Developmental cell · 2022Article
- FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells.Cells · 2022Article
- CMV enhancer may not be suitable for tissue-specific enhancement of promoters in cancer gene therapy.Cancer gene therapy · 2020Article
- YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis.Nature communications · 2019Article
- Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer.EBioMedicine · 2017Review
- NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer.Oncotarget · 2016Article
- Article
- Expression of lung surfactant proteins SP-B and SP-C and their modulating factors in fetal lung of FGR rats.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2015Article
- Benign Hereditary Chorea: An Update.Tremor and other hyperkinetic movements (New York, N.Y.) · 2015Review
- NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence.Genes & development · 2013Article
- Deletion of STK40 protein in mice causes respiratory failure and death at birth.The Journal of biological chemistry · 2013Article
- Nkx2-1: a novel tumor biomarker of lung cancer.Journal of Zhejiang University. Science. B · 2012Review
- Article
- Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation.Developmental biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Surfactant protein C (SP-C; Sftpc) gene expression is restricted to pulmonary type II epithelial cells. The proximal SP-C promoter region contains critical binding sites for nuclear factor I (NFI) and thyroid transcription factor 1 (TTF-1; also called Nkx2.1). To test the hypothesis that NFI isoforms interact with TTF-1 to differentially regulate SP-C transcription, we performed transient transfection assays in JEG-3 cells, a choriocarcinoma cell line with negligible endogenous NFI or TTF-1 activity. Cotransfection of NFI family members with TTF-1 induced synergistic activation of the SP-C promoter that was further enhanced by p300. TTF-1 directly interacts with the conserved DNA binding and dimerization domain of all NFI family members in coimmunoprecipitation and mammalian two-hybrid experiments. To determine whether SP-C expression is regulated by NFI in vivo, a chimeric fusion protein containing the DNA binding and dimerization domain of NFI-A and the Drosophila engrailed transcriptional repression domain (NFIen) was conditionally expressed in mice under control of a doxycycline-inducible transgene. Induction of NFIen in a subset of type II cells inhibited SP-C gene expression without affecting expression of TTF-1 in doxycycline-treated double-transgenic mice. Taken together, these findings support the hypothesis that NFI family members interact with TTF-1 to regulate type II cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.