ArticleMolecular and cellular biology2003
Genomic imprinting controls matrix attachment regions in the Igf2 gene.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
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- Cell-Specific PEAR1 Methylation Studies Reveal a Locus that Coordinates Expression of Multiple Genes.International journal of molecular sciences · 2018Article
- The role of long non-coding RNAs in genome formatting and expression.Frontiers in genetics · 2015Review
- Myc-induced anchorage of the rDNA IGS region to nucleolar matrix modulates growth-stimulated changes in higher-order rDNA architecture.Nucleic acids research · 2014Article
- Chromatin loop organization of the junb locus in mouse dendritic cells.Nucleic acids research · 2013Article
- Review
- Long-range chromatin interactions at the mouse Igf2/H19 locus reveal a novel paternally expressed long non-coding RNA.Nucleic acids research · 2011Article
- eXIST with matrix-associated proteins.Trends in cell biology · 2011Article
- Addition of H19 'loss of methylation testing' for Beckwith-Wiedemann syndrome (BWS) increases the diagnostic yield.The Journal of molecular diagnostics : JMD · 2010Article
- Inter-MAR association contributes to transcriptionally active looping events in human beta-globin gene cluster.PloS one · 2009Article
- A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression.Molecular and cellular biology · 2008Article
- Genomic imprinting of IGF2 in marsupials is methylation dependent.BMC genomics · 2008Article
- Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.Molecular and cellular biology · 2006Article
- Phylogenetic footprint analysis of IGF2 in extant mammals.Genome research · 2004Article
- The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic imprinting at the Igf2/H19 locus originates from allele-specific DNA methylation, which modifies the affinity of some proteins for their target sequences. Here, we show that AT-rich DNA sequences located in the vicinity of previously characterized differentially methylated regions (DMRs) of the imprinted Igf2 gene are conserved between mouse and human. These sequences have all the characteristics of matrix attachment regions (MARs), which are known as versatile regulatory elements involved in chromatin structure and gene expression. Combining allele-specific nuclear matrix binding assays and real-time PCR quantification, we show that retention of two of these Igf2 MARs (MAR0 and MAR2) in the nuclear matrix fraction depends on the tissue and is specific to the paternal allele. Furthermore, on this allele, the Igf2 MAR2 is functionally linked to the neighboring DMR2 while, on the maternal allele, it is controlled by the imprinting-control region. Our work clearly demonstrates that genomic imprinting controls matrix attachment regions in the Igf2 gene.
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