ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Corpus callosum deficiency in transgenic mice expressing a truncated ephrin-A receptor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Bridging the anatomical gap: evolutionary conservation of genetic mechanisms in corpus callosum disorders across human, mouse, and zebrafish.Frontiers in molecular neuroscience · 2026Review
- Glial interactions in the formation and plasticity of the corpus callosum.Frontiers in cellular neuroscience · 2025Review
- Astrocytes of the Anterior Commissure Regulate the Axon Guidance Pathways of Newly Generated Neocortical Neurons in the OpossumInternational journal of molecular sciences · 2024Article
- Article
- PlexinA1 is crucial for the midline crossing of callosal axons during corpus callosum development in BALB/cAJ mice.PloS one · 2019Article
- EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure.Developmental neurobiology · 2016Article
- Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.PloS one · 2015Article
- 'Til Eph do us part': intercellular signaling via Eph receptors and ephrin ligands guides cerebral cortical development from birth through maturation.Cerebral cortex (New York, N.Y. : 1991) · 2013Review
- Activity-dependent callosal axon projections in neonatal mouse cerebral cortex.Neural plasticity · 2012Review
- Segregation and pathfinding of callosal axons through EphA3 signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Development, specification, and diversity of callosal projection neurons.Trends in neurosciences · 2011Review
- EphA3 functions are regulated by collaborating phosphotyrosine residues.Cell research · 2010Article
- Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development.PloS one · 2010Article
- c-Fos expression during temporal order judgment in mice.PloS one · 2010Article
- Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.PLoS biology · 2009Article
- Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism.Genes & development · 2009Article
- Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling.Development (Cambridge, England) · 2009Article
- Changes in attack behavior and activity in EphA5 knockout mice.Brain research · 2008Article
- Reverse signaling via a glycosyl-phosphatidylinositol-linked ephrin prevents midline crossing by migratory neurons during embryonic development in Manduca.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The A-class of the erythropoietin-producing hepatocellular carcinoma cell-derived (EphA) tyrosine kinase receptors and their ligands, the A-ephrins, play critical roles in the specification of topographic axon projection maps during development. In this study, the role of the EphA subfamily in callosal projections was investigated using transgenic mice expressing a kinase deletion mutant of EphA5. In approximately half of these transgenic mice, cerebral cortical neurons in various cortical regions (primary and secondary somatosensory cortices and frontal as well as visual areas) failed to project to the contralateral cortex. When commissural axons were examined with DiI labeling, few callosal fibers were found to traverse the midline in both the adult and neonatal transgenic mice. This defect in callosal development correlates with the expression of the transgene, because neurons in the superficial layers of the motor cortex, where transgene expression is low, show normal contralateral projection through the corpus callosum. In addition, multiple EphA receptors are expressed in callosal neurons and ephrin-A5 stimulates neurite outgrowth of callosal neurons in vitro. The midline glia structures important for callosal axon midline crossing appear normal in the transgenic mice, suggesting that the defects are unrelated to defective guidance structures at the midline. These observations suggest critical functions for EphA receptor in establishing callosal connections during brain development.
Indexed as
Identifiers
14645492PMC6740996W1683488899What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.