Evidence map›Paper›PMID 14645429›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2003

High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the Late Effects Study Group.

Smita Bhatia, Yutaka Yasui, Leslie L Robison, Jillian M Birch, Monica K Bogue, Lisa Diller, Cyndi DeLaat, Franca Fossati-Bellani, Elaine Morgan, Odile Oberlin and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 11 pooled it
31.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 11 syntheses or guidelines pooled it, 617 citations in OpenAlex.

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111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Smita BhatiaCity of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010-3000, USA. sbhatia@coh.org
Yutaka Yasui
Leslie L Robison
Jillian M Birch
Monica K Bogue
Lisa Diller
Cyndi DeLaat
Franca Fossati-Bellani
Elaine Morgan
Odile Oberlin
Gregory Reaman
Frederick B Ruymann
Jean Tersak
Anna T Meadows
Late Effects Study Group
Children's National · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe present an update of a previously reported Late Effects Study Group cohort of 1,380 children with Hodgkin's disease (HD) diagnosed between 1955 and 1986 in patients aged 16 years or younger. We describe the pattern and incidence of subsequent neoplasms (SNs) occurring with extended follow-up. PATIENTS AND

methodsMedian age at diagnosis of HD was 11.7 years (range, 0.3 to 16.9 years) and at last follow-up was 27.8 years. Median length of follow-up was 17.0 years.

resultsAn additional 103 SNs were ascertained (total SNs = 212). The cohort was at an 18.5-fold increased risk of developing SNs compared with the general population (standardized incidence ratio [SIR], 18.5, 95% CI, 15.6 to 21.7). The cumulative incidence of any second malignancy was 10.6% at 20 years, increasing to 26.3% at 30 years; and of solid malignancies was 7.3% at 20 years, increasing to 23.5% at 30 years. Breast cancer was the most common solid malignancy (SIR, 56.7). Other commonly occurring solid malignancies included thyroid cancer (SIR, 36.4), bone tumors (SIR, 37.1), and colorectal (SIR, 36.4), lung (SIR, 27.3), and gastric cancers (SIR, 63.9). Risk factors for solid tumors included young age at HD and radiation-based therapy. Thirty-two patients developed third neoplasms, with the cumulative incidence approaching 21% at 10 years from diagnosis of second malignancy.

conclusionAdditional follow-up of this large cohort of HD survivors documents an increasing occurrence of known radiation-associated solid tumors, (breast and thyroid cancers), as well as emergence of epithelial neoplasms common in adults, (colon and lung cancers) at a younger age than expected in the general population, necessitating ongoing surveillance of this high risk population.

Indexed as

AdolescentAdultAge DistributionChildChild, PreschoolCohort StudiesFemaleFollow-Up StudiesHodgkin DiseaseHumansIncidenceInfantInfant, NewbornMaleNeoplasms, Second PrimaryRisk Factors

Identifiers

PMID14645429
OpenAlexW2105900079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.