ArticleJournal of neurophysiology2004
Photolysis of postsynaptic caged Ca2+ can potentiate and depress mossy fiber synaptic responses in rat hippocampal CA3 pyramidal neurons.
Article in Journal of neurophysiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Prenatal Stress Induced by Maternal Immune Activation Disrupts GABAergic Inhibition and Mossy Fiber Plasticity in the Rat Dentate Gyrus-CA3 Circuit.Hippocampus · 2026Article
- Physiological signature of a novel potentiator of AMPA receptor signalling.Molecular and cellular neurosciences · 2018Article
- Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD.Nature neuroscience · 2018Article
- Alcohol induces input-specific aberrant synaptic plasticity in the rat dorsomedial striatum.Neuropharmacology · 2017Article
- Information processing and synaptic plasticity at hippocampal mossy fiber terminals.Frontiers in cellular neuroscience · 2014Review
- Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Combining voltage and calcium imaging from neuronal dendrites.Cellular and molecular neurobiology · 2008Article
- Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Simultaneous NMDA-dependent long-term potentiation of EPSCs and long-term depression of IPSCs in cultured rat hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Gene targeting of presynaptic proteins in synaptic plasticity and memory: across the great divide.Neurobiology of learning and memory · 2006Review
- Active zones for presynaptic plasticity in the brain.Molecular psychiatry · 2005Review
- GABA-mediated giant depolarizing potentials as coincidence detectors for enhancing synaptic efficacy in the developing hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Retrograde Suppression of Post-Tetanic Potentiation at the Mossy Fiber-CA3 Pyramidal Cell Synapse.eNeuroArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
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Abstract
The induction of mossy fiber-CA3 long-term potentiation (LTP) and depression (LTD) has been variously described as being dependent on either pre- or postsynaptic factors. Some of the postsynaptic factors for LTP induction include ephrin-B receptor tyrosine kinases and a rise in postsynaptic Ca2+ ([Ca2+]i). Ca2+ is also believed to be involved in the induction of the various forms of LTD at this synapse. We used photolysis of caged Ca2+ compounds to test whether a postsynaptic rise in [Ca2+]i is sufficient to induce changes in synaptic transmission at mossy fiber synapses onto rat hippocampal CA3 pyramidal neurons. We were able to elevate postsynaptic [Ca2+]i to approximately 1 microm for a few seconds in pyramidal cell somata and dendrites. We estimate that CA3 pyramidal neurons have approximately fivefold greater endogenous Ca2+ buffer capacity than CA1 neurons, limiting the rise in [Ca2+]i achievable by photolysis. This [Ca2+]i rise induced either a potentiation or a depression at mossy fiber synapses in different preparations. Neither the potentiation nor the depression was accompanied by consistent changes in paired-pulse facilitation, suggesting that these forms of plasticity may be distinct from synaptically induced LTP and LTD at this synapse. Our results are consistent with a postsynaptic locus for the induction of at least some forms of synaptic plasticity at mossy fiber synapses.
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