ArticleThe Journal of biological chemistry2004
The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner.
Article in The Journal of biological chemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Comprehending the crosstalk between Notch, Wnt and Hedgehog signaling pathways in oral squamous cell carcinoma - clinical implications.Cellular oncology (Dordrecht, Netherlands) · 2021Review
- The small GTPase Rap1 is a modulator of Hedgehog signaling.Developmental biology · 2016Article
- Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2.Cell research · 2012Article
- The Hedgehog signal transduction network.Science signaling · 2012Review
- Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila.Mechanisms of development · 2012Article
- Unconventional functions of microtubule motors.Archives of biochemistry and biophysics · 2012Review
- The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.Development (Cambridge, England) · 2012Article
- The Hedgehog signalling pathway regulates autophagy.Nature communications · 2012Article
- Mechanism and evolution of cytosolic Hedgehog signal transduction.Development (Cambridge, England) · 2010Review
- A quantification of pathway components supports a novel model of Hedgehog signal transduction.The Journal of biological chemistry · 2009Article
- Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.Genes & development · 2009Article
- G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.Nature · 2008Article
- Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway.Current biology : CB · 2008Article
- Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms.The Journal of biological chemistry · 2006Article
- Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development.Molecular and cellular biology · 2005Article
- An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling.Molecular and cellular biology · 2004Article
- Suppressor of fused regulates Gli activity through a dual binding mechanism.Molecular and cellular biology · 2004Article
- Regulation of Hedgehog signaling: a complex story.Biochemical pharmacology · 2004Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
In Drosophila, Hedgehog (Hh) signal transduction has been shown to require a multiprotein complex (Hedgehog signaling complex (HSC)), which includes the Kinesin-related protein Costal2 (Cos2), the serine/threonine protein kinase Fused (Fu), and the transcription factor Cubitus interruptus (Ci). We present evidence that a biologically relevant fraction of the HSC is found in association with cellular membranes. We demonstrate that Cos2 is capable of tethering an exogenous protein to vesicular membranes and that Cos2 association with membranes is Hh-sensitive. In addition, we demonstrate that Cos2 associates with membranes in cells that lack the transmembrane protein Smoothened (Smo) through a domain of Cos2 distinct from its recently characterized Smo binding domain. We suggest that an Hh-regulated membrane binding activity of Cos2 is part of the mechanism by which Cos2 contributes to Hh signaling. We propose a model in which there are two distinct HSCs with discrete subcellular localizations and activities: one is endosome-associated and facilitates production of a repressor form of Ci (HSC-R), and one is Smo-associated and promotes Ci activation (HSC-A). In response to Hh and through interaction with Cos2, Smo mediates both inhibition of the endosome-associated HSC-R and activation of HSC-A at the plasma membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.