ArticleJournal of clinical pathology2003
Mannan binding lectin in febrile adults: no correlation with microbial infection and complement activation.
Article in Journal of clinical pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- The ambiguous role of mannose-binding lectin (MBL) in human immunity.Open medicine (Warsaw, Poland) · 2021Review
- Mannose-binding lectin (MBL) as prognostic factor in paediatric oncology patients.Clinical and experimental immunology · 2011Article
- Article
- Mannose-binding lectin deficiency facilitates abdominal Candida infections in patients with secondary peritonitis.Clinical and vaccine immunology : CVI · 2008Article
- Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study.Arthritis research & therapy · 2008Article
- Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis.Clinical and experimental immunology · 2007Article
- Mannose-binding lectin in innate immunity: past, present and future.Tissue antigens · 2006Review
- Clinical manifestations of mannan-binding lectin deficiency.Molecular immunology · 2006Review
- Mannan-binding lectin and procalcitonin measurement for prediction of postoperative infection.Critical care (London, England) · 2005Article
- Is there a role for mannan/mannose-binding lectin (MBL) in defence against infection following chemotherapy for cancer?Clinical and experimental immunology · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo study the role of the mannan binding lectin (MBL) pathway of complement activation in the host defence to microbial infection in vivo, and the role of MBL in infectious mortality in non-selected patients.
methodsA prospective observational study on 177 hospitalised medical patients with new onset fever. The presence, origin, and microbial cause of infection, the circulating MBL and complement activation product 3a (C3a), and the 28 day hospital course were determined.
resultsThe patients had median MBL values similar to healthy blood donors: 18% of the patients and 14% of the blood donors had MBL deficiency, with values below 0.1 microg/ml. Median C3a was higher in patients with microbiologically confirmed infection than in those without, whereas there was no difference in MBL values or frequency of deficiency among patient groups with or without positive local cultures or bacteraemia. The mortality rate was 8% and the outcome groups did not differ in MBL. In febrile adults hospitalised in internal medicine wards, microbial infection induces complement activation, independently of MBL.
conclusionsThe results argue against a predominant role for the MBL pathway of complement activation and a deficiency of MBL predisposing to serious and invasive microbial infection in non-selected adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.