ArticleJournal of clinical pathology2003
Salivary duct carcinoma: immunohistochemical profile of an aggressive salivary gland tumour.
Article in Journal of clinical pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Evaluation of HER2/neu expression in different types of salivary gland tumors: a systematic review and meta-analysis.Journal of medicine and life · 2022Pooled it
- Nomograms predicting cancer-specific survival and overall survival of advanced salivary gland malignancy patients: a study based on the SEER database.Discover oncology · 2025Article
- Frequency of and sex differences in cancer treatment-related cardiac dysfunction in trastuzumab-treated patients with salivary gland cancer: a retrospective cohort study.Cardio-oncology (London, England) · 2024Article
- A case of carcinoma ex pleomorphic adenoma arising from multinodular pleomorphic adenoma of the buccal region.Clinical case reports · 2019Article
- The expression of PD-L1 in salivary gland carcinomas.Scientific reports · 2019Article
- Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy.Oral oncology · 2017Review
- Establishment and genomic characterization of primary salivary duct carcinoma cell line.Oral oncology · 2017Article
- Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: a multi-institutional study in Japan.Oncotarget · 2017Article
- Article
- Pathological response of salivary duct carcinoma to trastuzumab and docetaxel therapy.International cancer conference journal · 2016Article
- Clinical Outcomes and Prognostic Factors for Salivary Duct Carcinoma: A Multi-Institutional Analysis of 141 Patients.Annals of surgical oncology · 2016Article
- Dysregulation of the Rb pathway in recurrent pleomorphic adenoma of the salivary glands.Virchows Archiv : an international journal of pathology · 2015Article
- Human Epidermal Growth Factor Receptor 2 (HER2/neu) in Salivary Gland Carcinomas: A Review of Literature.Journal of clinical and diagnostic research : JCDR · 2015Review
- Breast metastasis of salivary duct carcinoma in a patient: a case report.International journal of clinical and experimental medicine · 2015Article
- An immunohistochemical panel for reliable differentiation of salivary duct carcinoma and mucoepidermoid carcinoma.Head and neck pathology · 2014Article
- Article
- Perineural spread of salivary duct carcinoma to the internal auditory canal.Case reports in otolaryngology · 2014Article
- Maintenance therapy with trastuzumab in her2 positive metastatic parotid ductal adenocarcinoma.Case reports in oncological medicine · 2014Article
- Management and outcome of salivary duct carcinoma in major salivary glands.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Salivary duct carcinoma of the parotid gland.Journal of oral and maxillofacial pathology : JOMFP · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSalivary duct carcinoma (SDC) is considered to be a distinct malignancy of the major salivary glands, because of its highly aggressive behaviour, and the high rate of recurrence, metastasis, and disease related death.
aimsTo investigate expression of the proteins involved in the retinoblastoma (pRb) and p53 pathways, which control cell cycle progression at the G1/S checkpoint, and also expression of the c-erbB-2 oncoprotein in SDCs.
methodsUsing a streptavidin-biotin method, five cases of SDC were evaluated immunohistochemically for the presence of cyclin D1, CDK4 (cyclin dependent kinase 4), p16 (CDK2A), pRb (retinoblastoma protein), E2F-1, p53, mdm2 (murine double minute 2), bcl-2, and the c-erbB-2 oncoprotein to determine whether there was a correlation between the expression of these proteins and patient outcome.
resultsAll of the cases showed deregulation of the pRb and p53 pathways. Of the five patients analysed, only the patient with longterm survival (10 years) was not positive for c-erbB-2 expression.
conclusionsc-erbB-2 overexpression was associated with a poor prognosis. Aggressive behaviour, recurrence, and metastatic potential do not appear to be related to cell cycle deregulation, but seem to be associated with the c-erbB-2 oncoprotein, which is involved in matrix degradation and proteolitic activity, in addition to increases in vessel permeability, endothelial cell growth, proliferation, migration, and differentiation. There was a correlation between c-erbB-2 oncoprotein expression and aggressive behaviour in SDCs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.