ArticleJournal of clinical pathology2003
Immunohistochemical analysis of adenocarcinoma of the small intestine: a tissue microarray study.
Article in Journal of clinical pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine.Acta histochemica et cytochemica · 2015Article
- Small bowel adenocarcinoma phenotyping, a clinicobiological prognostic study.British journal of cancer · 2013Article
- Small bowel adenocarcinomas--existing evidence and evolving paradigms.Nature reviews. Clinical oncology · 2013Review
- DPC4 expression in the small intestinal adenocarcinomas.Korean journal of pathology · 2012Article
- Recent advances in the management of adenocarcinoma of the small intestine.Gastrointestinal cancer research : GCR · 2009Article
- Feasibility of screening for Lynch syndrome among patients with colorectal cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2008Article
- Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association?International journal of gastrointestinal cancer · 2006Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary adenocarcinomas of the small intestine are rare, and the genetic mechanisms involved in their carcinogenesis remain unclear.
aimTo examine the expression of candidate proteins in small intestinal adenocarcinomas by immunohistochemistry performed on tissue microarrays (TMAs).
methodsTwenty seven primary sporadic small intestinal adenocarcinomas were analysed. The TMA technique was validated by comparing immunohistochemical labelling of hMLH1 and hMSH2 on TMAs and the tissue sections they derived from. The expression of Smad4, hMSH6, beta catenin, and p53 was investigated and results compared with those obtained in 14 malignant ampullary tumours.
resultsTMA technology with threefold redundancy adequately represented the immunohistochemical pattern of small intestinal adenocarcinomas. Loss of hMLH1 expression, but not hMSH2 or hMSH6, was seen in two of 27 small intestinal adenocarcinomas. All ampullary tumours showed nuclear staining for hMSH2 and hMSH6. One case showed lack of immunostaining for hMLH1. Smad4 expression was absent in five small intestinal adenocarcinomas and two ampullary tumours. Overexpression of p53 was detected in the nuclei of 14 of the 27 small intestinal adenocarcinomas, and five of the 14 ampullary tumours. Nuclear or cytoplasmic expression of beta catenin was present in all specimens.
conclusionInactivation of the SMAD4/DPC4 gene seems to be involved in small intestinal adenocarcinoma tumorigenesis. Overexpression of p53 and abnormal expression of beta catenin are two common events, unlike the loss of expression of the DNA mismatch repair proteins (hMLH1, hMSH2, and hMSH6). The carcinogenetic process appears to be similar in small intestinal adenocarcinomas and malignant ampullary tumours.
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