ArticleThe Journal of biological chemistry2004
Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression.
Article in The Journal of biological chemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Mammalian conservation of endogenous G-quadruplex reveals their associations with complex traits.Genome biology · 2025Article
- Review
- CCAAT Promoter element regulates transgenerational expression of the MHC class I gene.Chromosoma · 2024Article
- Differential metabolic reprogramming in developing soybean embryos in response to nutritional conditions and abscisic acid.Plant molecular biology · 2023Article
- Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin.Nature genetics · 2021Article
- Transcription factor competition at the γ-globin promoters controls hemoglobin switching.Nature genetics · 2021Article
- The animal nuclear factor Y: an enigmatic and important heterotrimeric transcription factor.American journal of cancer research · 2018Review
- Transcription factor NF-Y is involved in differentiation of R7 photoreceptor cell in Drosophila.Biology open · 2012Article
- Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells.PloS one · 2012Article
- Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor.Brain : a journal of neurology · 2011Article
- Comparative analysis of the ATRX promoter and 5' regulatory region reveals conserved regulatory elements which are linked to roles in neurodevelopment, alpha-globin regulation and testicular function.BMC research notes · 2011Article
- Article
- The higher structure of chromatin in the LCR of the beta-globin locus changes during development.Journal of molecular biology · 2009Article
- Autonomous silencing as well as competition controls gamma-globin gene expression during development.Molecular and cellular biology · 2006Article
- Phylogenetic comparisons suggest that distance from the locus control region guides developmental expression of primate beta-type globin genes.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Transcriptional potential of the gamma-globin gene is dependent on the CACCC box in a developmental stage-specific manner.Nucleic acids research · 2006Article
- Inhibition of CBF/NF-Y mediated transcription activation arrests cells at G2/M phase and suppresses expression of genes activated at G2/M phase of the cell cycle.Nucleic acids research · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The CCAAT box is a widespread motif in eukaryotic promoters. In this study we demonstrate that the effects of the CCAAT box on gamma-globin gene activation are developmentally distinct. Although this promoter element is essential for high level gamma gene expression in adult erythropoiesis, it plays little role in embryonic erythroid cells. The CCAAT mutation in the human gamma-globin gene promoter impairs recruitment of TATA-binding protein (TBP), TFIIB, and RNA polymerase II in adult splenic erythroblasts but not in embryonic erythroid cells. We also show that the efficiency of gamma gene transcription is correlated with recruitment of TBP on the TATA box but that the level of TBP recruitment is not nuclear factor Y (NF-Y)-dependent. Our data also suggest that it is unlikely that transcriptional stimulation by the CCAAT box is exerted through direct protein-protein interaction between NF-Y and TBP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.