ArticleBritish journal of pharmacology2003
Inhibition of human alpha 7 nicotinic acetylcholine receptors by open channel blockers of N-methyl-D-aspartate receptors.
Article in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 80 citations in OpenAlex.
- Assessing the translational feasibility of pharmacological drug memory reconsolidation blockade with memantine in quitting smokers.Psychopharmacology · 2015Trial
- Randomized Placebo-Controlled Trial of Memantine for Smoking Cessation (CCCWFU 99311).Cancer control : journal of the Moffitt Cancer CenterTrial
- Inhibition of NMDA receptors and other ion channel types by membrane-associated drugs.Frontiers in pharmacology · 2025Review
- Cure of Alzheimer's Dementia Requires Addressing All of the Affected Brain Cell Types.Journal of clinical medicine · 2023Article
- Supplementary Pharmacotherapy for the Behavioral Abnormalities Caused by Stressors in Humans, Focused on Post-Traumatic Stress Disorder (PTSD).Journal of clinical medicine · 2023Article
- Formulating treatment of major psychiatric disorders: algorithm targets the dominantly affected brain cell-types.Discover mental health · 2023Review
- Memantine has a nicotinic neuroprotective pathway in acute hippocampal slices after an NMDA insult.Toxicology in vitro : an international journal published in association with BIBRA · 2022Article
- Is Memantine Effective as an NMDA-Receptor Antagonist in Adjunctive Therapy for Schizophrenia?Biomolecules · 2020Review
- Alzheimer's Disease Therapeutic Approaches.Advances in experimental medicine and biology · 2020Review
- Prevention of Alzheimer's disease by treating mild cognitive impairment with combinations chosen from eight available drugs.Alzheimer's & dementia (New York, N. Y.) · 2019Review
- Effects of MgNeuropharmacology · 2018Article
- Memantine and Ketamine Differentially Alter NMDA Receptor Desensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Therapeutics of Neurotransmitters in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2017Review
- Recent insights into the mode of action of memantine and ketamine.Current opinion in pharmacology · 2015Review
- From single target to multitarget/network therapeutics in Alzheimer's therapy.Pharmaceuticals (Basel, Switzerland) · 2014Article
- Comparison of behavioral effects of the NMDA receptor channel blockers memantine and ketamine in rats.Pharmacology, biochemistry, and behavior · 2013Article
- Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum.Advances in experimental medicine and biology · 2012Review
- Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.PloS one · 2012Article
- Total synthesis of pinnatoxins A and G and revision of the mode of action of pinnatoxin A.Journal of the American Chemical Society · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Human alpha 7 nicotinic acetylcholine (ACh) receptors were expressed in Xenopus oocytes and the effects of the N-methyl-D-aspartate (NMDA) receptor open channel blockers memantine and cerestat on this receptor were examined using two-electrode voltage-clamp recordings and 125I-alpha-bungarotoxin (125I-alpha-bgtx) binding. 2. Memantine and cerestat produced complete inhibition of ACh-induced inward currents with affinities similar to that reported for native NMDA receptors. Cerestat, IC50 1.7 (-1; +2) microm, was more potent than memantine, IC50 5 (-3;+8) microM, and the effects of both drugs were fully and rapidly reversible. 3. Inhibition of alpha 7 receptor function was voltage-independent, and it occurred at concentrations far lower than those needed to inhibit (never completely) binding of 125I-alpha-bgtx to alpha 7 receptors, suggesting that the effects of memantine or cerestat are noncompetitive. 4. These results provide evidence that human alpha 7 receptors are inhibited by memantine and cerestat and suggest that caution should be applied when using these compounds to study systems in which NMDA and nACh receptors co-exist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.