ReviewAnnals of the rheumatic diseases2003
A fibrin based model for rheumatoid synovitis.
Review in Annals of the rheumatic diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Article
- Inhibitory effects of Acanthopanax sessiliflorus Harms extract on the etiology of rheumatoid arthritis in a collagen-induced arthritis mouse model.Arthritis research & therapy · 2024Article
- Blood-Induced Arthropathy: A Major Disabling Complication of Haemophilia.Journal of clinical medicine · 2023Review
- Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency.Frontiers in immunology · 2020Article
- Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
- Changes in concentrations of haemostatic and inflammatory biomarkers in synovial fluid after intra-articular injection of lipopolysaccharide in horses.BMC veterinary research · 2017Article
- Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues.Arthritis and rheumatism · 2013Article
- Coagulation and the fibrin network in rheumatic disease: a role beyond haemostasis.Nature reviews. Rheumatology · 2012Review
- Nitric oxide-driven hypoxia initiates synovial angiogenesis, hyperplasia and inflammatory lesions in mice.PloS one · 2012Article
- Fibrinolysis is down-regulated in mouse collagen-induced arthritis, but its normalization does not alleviate the course of disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Autoimmunity against fibrinogen mediates inflammatory arthritis in mice.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptides in rheumatoid arthritis.Arthritis research & therapy · 2009Article
- Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis.Arthritis research & therapy · 2008Article
- Expression of the peptide C4b-binding protein beta in the arthritic joint.Annals of the rheumatic diseases · 2006Article
- Citrullinated fibrinogen detected as a soluble citrullinated autoantigen in rheumatoid arthritis synovial fluids.Annals of the rheumatic diseases · 2006Article
- Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.Arthritis research & therapy · 2006Article
- Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis.Inflammation · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracavitary fibrin clots may initiate pannus formation and the immunopathology of RA. Two critical steps, probably host dependent, may determine the development of RA: an altered regulation of extravascular haemostasis or an aberrant reactivity of synovial fibroblasts to the adhered fibrin clots. Current treatments for RA target events downstream of fibrin deposition, perhaps agents acting at an earlier stage should be tried.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.