ReviewAnnals of the rheumatic diseases2003
Cytokines in the seronegative spondyloarthropathies and their modification by TNF blockade: a brief report and literature review.
Review in Annals of the rheumatic diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 78 citations in OpenAlex.
- Effects of high-dose corticosteroids on post-traumatic inflammatory mediators.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2009Trial
- Potential of Circulating MicroRNA Panels to Discriminate Peripheral Arthritis in the Spondyloarthritis Spectrum: A Preliminary and Validation Study.Medicina (Kaunas, Lithuania) · 2026Article
- Significant correlations of upregulated MPO expression with cytokine imbalance in ankylosing spondylitis patients and the inhibitory effect mediated by mesenchymal stem cells.BMC musculoskeletal disorders · 2025Article
- Axial Spondyloarthritis: an overview of the disease.Rheumatology international · 2024Review
- The Long-Term Effects of Short-Period Adalimumab Biosimilar Usage in Ankylosing Spondylitis.Cureus · 2023Article
- Recent Updates in Juvenile Spondyloarthritis.Rheumatic diseases clinics of North America · 2021Review
- Influence ofFrontiers in immunology · 2021Observational
- Genetic variations in the IL-12B gene in association with IL-23 and IL-12p40 serum levels in ankylosing spondylitis.Rheumatology international · 2019Article
- Effect of Carnosine in Experimental Arthritis and on Primary Culture Chondrocytes.Oxidative medicine and cellular longevity · 2016Article
- Interleukin-1 associations in inflammatory bowel disease and the enteropathic seronegative spondylarthritis.Auto- immunity highlights · 2013Article
- Molecular control of steady-state dendritic cell maturation and immune homeostasis.Annual review of immunology · 2013Review
- Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis.Arthritis research & therapy · 2012Article
- Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response.Arthritis and rheumatism · 2011Article
- Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.Nature immunology · 2011Article
- A pilot study of the association of tumor necrosis factor alpha polymorphisms with psoriatic arthritis in the Romanian population.International journal of molecular sciences · 2011Article
- Rodent preclinical models for developing novel antiarthritic molecules: comparative biology and preferred methods for evaluating efficacy.Journal of biomedicine & biotechnology · 2011Review
- Biomarkers in spondyloarthritis.Current rheumatology reports · 2010Review
- The evolving systemic and local biomarker milieu at different stages of disease progression in rat adjuvant-induced arthritis.Journal of clinical immunology · 2009Article
- Management of ankylosing spondylitis with infliximab.Open access rheumatology : research and reviews · 2009Review
- RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFalpha or anti-IL-1 therapies.Arthritis research & therapy · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rheumatoid arthritis (RA) is a disease well characterised by proinflammatory cytokine secretion (particularly tumour necrosis factor, interferon gamma, interleukin (IL) 1, and IL6). Less has been reported about the cytokine profiling in the spondyloarthropathies (SpA). Several trials suggest that, similar to RA, proinflammatory cytokines are globally expressed in the SpA. However, other studies report a down regulation of these cytokines in the SpA, with a relative anti-inflammatory polarisation (featuring increases in IL4, IL5, and IL10). This review summarises current published reports and the variation in cytokine data in the SpA. Additionally, results of cytokine profiles in patients with ankylosing spondylitis before and after treatment with etanercept are reported.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.