ArticleEnvironmental health perspectives2003
In vitro activation of cord blood mononuclear cells and cytokine production in a remote coastal population exposed to organochlorines and methyl mercury.
Article in Environmental health perspectives, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Review
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- Gene×environment interactions in autism spectrum disorders.Current topics in developmental biology · 2023Review
- Serum cytokines are associated with n-3 polyunsaturated fatty acids and not with methylmercury measured in infant cord blood in the Seychelles child development study.Environmental research · 2022Article
- An overview of organic contaminants in indoor dust, their health impact, geographical distribution and recent extraction/analysis methods.Environmental geochemistry and health · 2022Review
- Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins.International journal of environmental research and public health · 2021Review
- Exposure to DDT from indoor residual spraying and biomarkers of inflammation among reproductive-aged women from South Africa.Environmental research · 2020Article
- The influence of sex, genotype, and dose on serum and hippocampal cytokine levels in juvenile mice developmentally exposed to a human-relevant mixture of polychlorinated biphenyls.Current research in toxicology · 2020Article
- Body Burden of Dichlorodiphenyl Dichloroethene (DDE) and Childhood Pulmonary Function.International journal of environmental research and public health · 2017Article
- In utero exposure to DDT and incidence of diarrhea among boys from tropical Mexico.Environmental research · 2017Article
- Can exposure to environmental chemicals increase the risk of diabetes type 1 development?BioMed research international · 2015Review
- Concentrations of persistent organic pollutants (POPs) and heavy metals in soil from San Luis Potosí, México.Environmental monitoring and assessment · 2015Article
- Assessment of the levels of DDT and DDE in soil and blood samples from Tabasco, Mexico.Environmental monitoring and assessment · 2012Article
- Current status of the epidemiologic evidence linking polychlorinated biphenyls and non-hodgkin lymphoma, and the role of immune dysregulation.Environmental health perspectives · 2012Review
- Evidence on the human health effects of low-level methylmercury exposure.Environmental health perspectives · 2012Review
- Serum concentrations of antibodies against vaccine toxoids in children exposed perinatally to immunotoxicants.Environmental health perspectives · 2010Article
- Allergy and sensitization during childhood associated with prenatal and lactational exposure to marine pollutants.Environmental health perspectives · 2010Article
- Cytokines and other immunological biomarkers in children's environmental health studies.Toxicology letters · 2007Review
- Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children.Environmental health perspectives · 2005Article
- Study on failures to disclose conflicts of interest in Environmental Health Perspectives.Environmental health perspectives · 2004Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Remote coastal populations that rely on seafood for subsistence often receive unusually high doses of organochlorines and methyl mercury. Immunosuppression resulting from prenatal exposure to organochlorines has been reported in wildlife species and humans. In this study, we assessed lymphocyte activation and associated cytokine secretion in 47 newborns from a remote maritime population living on the Mid and Lower North Shore regions of the St. Lawrence River (Québec, Canada; subsistence fishing group) and 65 newborns from nearby urban settings (reference group). Cord blood samples were collected for organochlorine and mercury analyses and also to isolate cord blood mononuclear cells (CBMCs) for the in vitro assessment of cytokine production and expression of surface markers after mitogenic stimulation (CD4(+)CD45RO(+), CD8(+)CD45RO(+), CD3(+)CD25(+), and CD8(+)HLA-DR(+)). Blood mercury and plasma concentrations of polychlorinated biphenyls (PCBs), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p'-DDE), and hexachlorobenzene (HCB) were significantly higher in the subsistence fishing group than in the reference group (p < 0.001). No difference was observed between the two groups regarding subsets of lymphocytes showing markers of activation. In vitro secretion of cytokines by CBMCs after mitogenic stimulation was lower in the subsistence fishing group than in the reference group (p < 0.05). Moreover, we found an inverse correlation between tumor necrosis factor-alpha (TNF-alpha) secretion and plasma PCB, p,p'-DDE, and HCB concentrations (p < 0.05). Our data support a negative association between TNF-alpha secretion by CBMCs and prenatal organochlorine exposure. If the relationship between organochlorine and TNF-alpha secretion is causal, it would suggest a role for this important proinflammatory cytokine in mediating organochlorine-induced immunotoxicity in infants developmentally exposed to these compounds.
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