ArticleEnvironmental health perspectives2003
Hazardous effects of effluent from the chrome plating industry: 70 kDa heat shock protein expression as a marker of cellular damage in transgenic Drosophila melanogaster (hsp70-lacZ).
Article in Environmental health perspectives, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 65 citations in OpenAlex.
- Chrome Plating Facility Siting Is Associated with Neighborhood Demographic and Socioeconomic Factors and Elevated Per- and Polyfluoroalkyl Substances in Blood in California.Environmental science & technology · 2025Article
- Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools.Pharmaceutics · 2023Review
- Identification of therapeutic targets in a murine model of severe exertional heat stroke.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Heavy metal contamination in a highly consumed Brazilian fish: immunohistochemical and histopathological assessments.Environmental monitoring and assessment · 2020Article
- Evaluation of the toxic potential of arecoline toward the third instar larvae of transgenicToxicology research · 2018Article
- Exploration of teratogenic and genotoxic effects of fruit ripening retardant Alar (Daminozide) on model organismInterdisciplinary toxicology · 2018Article
- Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease.Disease models & mechanisms · 2016Article
- Stress Responses of Small Heat Shock Protein Genes in Lepidoptera Point to Limited Conservation of Function across Phylogeny.PloS one · 2015Article
- Synergistic effects of toxic elements on heat shock proteins.BioMed research international · 2014Review
- Article
- Effect of the steroid K-canrenoate on hsp70 expression and tissue damage in transgenic Drosophila melanogaster (hsp70-lacZ) Bg9.Journal of insect science (Online) · 2012Article
- Effect of methyl methanesulfonate on hsp70 expression and tissue damage in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg.Interdisciplinary toxicology · 2011Article
- Identification and characterization of heat shock 70 genes in Aedes aegypti (Diptera: Culicidae).Journal of medical entomology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hazardous effects of an effluent from the chrome plating industry were examined by exposing transgenic Drosophila melanogaster (hsp70-lacZ) to various concentrations (0.05, 0.1, 1.0, 10.0, and 100.0 micro L/mL) of the effluent through diet. The emergence pattern of adult flies was affected, along with impaired reproductive performance at the higher dietary concentrations of the effluent. Interestingly, the effect of the effluent was more pronounced in male than in female flies. The effect of the effluent on development of adult flies was concurrent with the expression pattern of the heat shock protein 70 gene (hsp70), both in larval tissues and in the reproductive organs of adult flies. We observed a dose- and time-dependent expression of hsp70 in third instar larvae exposed for different time intervals. Absence of hsp70 expression in larvae exposed to 0.1 micro L/mL of the effluent indicated that this is the highest nontoxic concentration for Drosophila. The stress gene assay in the reproductive organs of adult flies revealed hsp70 expression in the testis of male flies only. However, trypan blue dye exclusion tests in these tissues indicate tissue damage in the male accessory gland of adult flies, which was further confirmed by ultrastructural observations. In the present study we demonstrate the utility of transgenic Drosophila as an alternative animal model for evaluating hazardous effects of the effluent from the chrome plating industry and further reveal the cytoprotective role of hsp70 and its expression as an early marker in environmental risk assessment.
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