ArticleEnvironmental health perspectives2003
Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?
Article in Environmental health perspectives, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Effect of chlorpyrifos on VEGF gene expression.Chemico-biological interactions · 2023Article
- Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity.The Journal of biological chemistry · 2018Article
- Sex-Specific Neurotoxic Effects of Organophosphate Pesticides Across the Life Course.Current environmental health reports · 2017Review
- Developmental neurotoxicity of succeeding generations of insecticides.Environment international · 2017Review
- Determination of dichlorvos residue levels in vegetables sold in Lusaka, Zambia.The Pan African medical journal · 2016Article
- Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats.International journal of clinical and experimental medicine · 2015Article
- Methamidophos exposure during the early postnatal period of mice: immediate and late-emergent effects on the cholinergic and serotonergic systems and behavior.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity?Reproductive toxicology (Elmsford, N.Y.) · 2011Review
- Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos.Toxicology and applied pharmacology · 2010Article
- Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo.Brain research · 2010Article
- Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems.Brain research bulletin · 2007Article
- Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells.Environmental health perspectives · 2006Article
- A case for revisiting the safety of pesticides: a closer look at neurodevelopment.Environmental health perspectives · 2006Review
- Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood.Environmental health perspectives · 2005Article
- Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure.Environmental health perspectives · 2004Article
- Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling.Environmental health perspectives · 2004Article
- Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling.Environmental health perspectives · 2004Article
- Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The developmental neurotoxicity of chlorpyrifos (CPF) involves mechanisms over and above cholinesterase inhibition. In the present study, we evaluated the effects of gestational CPF exposure on the adenylyl cyclase (AC) signaling cascade, which regulates the production of cyclic AMP, a major controller of cell replication and differentiation. In addition to basal AC activity, we assessed the AC response to direct enzymatic stimulants [forskolin, manganese (Mn(2+))]; the response to isoproterenol, which activates signaling through beta-adrenoceptors (betaARs); and the concentration of betaAR binding sites. CPF administered to pregnant rats on gestational days (GD) 9-12 elicited little or no change in any components of AC activity or betaARs. However, shifting the treatment window to GD17-20 produced regionally selective augmentation of AC activity. In the brainstem, the response to forskolin or Mn(2+) was markedly stimulated by doses at or below the threshold for observable toxicity of CPF or for inhibition of fetal brain cholinesterase, whereas comparable effects were seen in the forebrain only at higher doses. In addition, low doses of CPF reduced betaAR binding without impairing receptor-mediated stimulation of AC. These results indicate that signal transduction through the AC cascade is a target for CPF during a discrete developmental period in late gestation, an effect that is likely to contribute to the noncholinergic component of CPF's developmental neurotoxicity.
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